PMID- 24468358
OWN - NLM
STAT- MEDLINE
DCOM- 20140919
LR  - 20140128
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 120
DP  - 2014 Mar
TI  - Chromatographic analysis with different detectors in the chemical 
      characterisation and dereplication of African propolis.
PG  - 181-90
LID - S0039-9140(13)00984-3 [pii]
LID - 10.1016/j.talanta.2013.11.094 [doi]
AB  - Propolis or bee glue has very diverse composition and is potentially a source of 
      biologically active compounds. Comprehensive chemical profiling was performed on 
      22 African propolis samples collected from the sub-Saharan region of Africa by 
      using various hyphenated analytical techniques including Liquid Chromatography 
      (LC)-UltraViolet Detection (UV)-Evaporative Light Scattering Detection (ELSD), 
      LC-High Resolution Mass Spectrometry (HRMS), Gas Chromatography (GC)-MS and 
      LC-Diode Array Detector (DAD)-HRMS/MS. The diversity of the composition of these 
      African propolis samples could be observed by heat mapping the LC-UV and ELSD 
      data. The characteristic chemical components were uncovered by applying Principal 
      Component Analysis (PCA) to the LC-HRMS data and a preliminary dereplication was 
      carried out by searching their accurate masses in the Dictionary of Natural 
      Products (DNP). A further identification was achieved by comparing their GC-MS or 
      LC-DAD-HRMS/MS spectra with previously published data. Generally no clear 
      geographic delineation was observed in the classification of these African 
      propolis samples. Triterpenoids were found as the major chemical components in 
      more than half of the propolis samples analysed in this study and some others 
      were classified as temperate and Eastern Mediterranean type of propolis. Based on 
      the comparative chemical profiling and dereplication studies one uncommon 
      propolis from southern Nigeria stood out from others by presenting prenylated 
      isoflavonoids, which indicated that it was more like Brazilian red propolis, and 
      more significantly a high abundance of stilbenoid compounds which could be novel 
      in propolis.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Zhang, Tong
AU  - Zhang T
AD  - University of Strathclyde, Department of Pharmaceutical Sciences, Strathclyde 
      Institute of Pharmacy and Biomedical Science, 27 Taylor Street, Glasgow G4 0NR, 
      UK. Electronic address: tong.zhang.101@strath.ac.uk.
FAU - Omar, Ruwida
AU  - Omar R
AD  - University of Strathclyde, Department of Pharmaceutical Sciences, Strathclyde 
      Institute of Pharmacy and Biomedical Science, 27 Taylor Street, Glasgow G4 0NR, 
      UK.
FAU - Siheri, Weam
AU  - Siheri W
AD  - University of Strathclyde, Department of Pharmaceutical Sciences, Strathclyde 
      Institute of Pharmacy and Biomedical Science, 27 Taylor Street, Glasgow G4 0NR, 
      UK.
FAU - Al Mutairi, Sultan
AU  - Al Mutairi S
AD  - University of Strathclyde, Department of Pharmaceutical Sciences, Strathclyde 
      Institute of Pharmacy and Biomedical Science, 27 Taylor Street, Glasgow G4 0NR, 
      UK.
FAU - Clements, Carol
AU  - Clements C
AD  - University of Strathclyde, Department of Pharmaceutical Sciences, Strathclyde 
      Institute of Pharmacy and Biomedical Science, 27 Taylor Street, Glasgow G4 0NR, 
      UK.
FAU - Fearnley, James
AU  - Fearnley J
AD  - BeeVital, Whitby, North Yorkshire YO22 5JR, UK.
FAU - Edrada-Ebel, RuAngelie
AU  - Edrada-Ebel R
AD  - University of Strathclyde, Department of Pharmaceutical Sciences, Strathclyde 
      Institute of Pharmacy and Biomedical Science, 27 Taylor Street, Glasgow G4 0NR, 
      UK.
FAU - Watson, David
AU  - Watson D
AD  - University of Strathclyde, Department of Pharmaceutical Sciences, Strathclyde 
      Institute of Pharmacy and Biomedical Science, 27 Taylor Street, Glasgow G4 0NR, 
      UK.
LA  - eng
PT  - Journal Article
DEP - 20131211
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Stilbenes)
RN  - 9009-62-5 (Propolis)
SB  - IM
MH  - Africa South of the Sahara
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Mass Spectrometry/methods
MH  - Principal Component Analysis
MH  - Propolis/*chemistry
MH  - Stilbenes/*analysis
OTO - NOTNLM
OT  - Chemical profiling
OT  - Dereplication
OT  - Liquid Chromatography-High Resolution Mass Spectometry (LC-HRMS)
OT  - Principal Component Analysis (PCA)
OT  - Propolis
OT  - Stilbenoid
EDAT- 2014/01/29 06:00
MHDA- 2014/09/23 06:00
CRDT- 2014/01/29 06:00
PHST- 2013/10/06 00:00 [received]
PHST- 2013/11/26 00:00 [revised]
PHST- 2013/11/30 00:00 [accepted]
PHST- 2014/01/29 06:00 [entrez]
PHST- 2014/01/29 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
AID - S0039-9140(13)00984-3 [pii]
AID - 10.1016/j.talanta.2013.11.094 [doi]
PST - ppublish
SO  - Talanta. 2014 Mar;120:181-90. doi: 10.1016/j.talanta.2013.11.094. Epub 2013 Dec 
      11.