PMID- 24468366
OWN - NLM
STAT- MEDLINE
DCOM- 20140919
LR  - 20191210
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 120
DP  - 2014 Mar
TI  - Analysis of 7 synthetic musks in cream by supported liquid extraction and solid 
      phase extraction followed by GC-MS/MS.
PG  - 248-54
LID - S0039-9140(13)00974-0 [pii]
LID - 10.1016/j.talanta.2013.11.086 [doi]
AB  - A new method for the simultaneous determination of 7 synthetic musks (musk 
      amberette, musk tibetene, musk moskene, musk ketone, musk xylene, phantolide, and 
      tonalide) in cream by means of supporting liquid extraction (SLE) coupled with 
      LC-Alumina-N SPE, then followed by GC-MS/MS has been established. In this study, 
      7 synthetic musks are extracted and pre-purified by a mixture solution of water 
      and isopropanol from cream, and separated and purified by tandem columns 
      containing SLE column and LC-Alumina-N SPE column, which were seldom reported 
      before. Ultrasonic and mechanical shaking were applied to improve the extraction 
      efficiency. Different experiment conditions, such as the type of extraction 
      solution, extraction time of ultrasonic and mechanical shaking, the type of SLE 
      and SPE column, and matrix effects were optimized and the recoveries of 7 
      synthetic musks for each part were above 86.61%. In addition, the use of isotope 
      internal standards was systemically discussed. The method showed satisfactory 
      linearity over the range assayed (5-1000 ng g(-1)), and the limits of detections 
      (LODs) ranged from 0.15 to 4.86 ng g(-1), and the limits of quantifications 
      (LOQs) were ranging from 0.49 to 16.21 ng g(-1). The recoveries using this method 
      at three spiked concentration levels (10, 100, and 1000 ng g(-1)) range from 
      85.6% to 109%. The relative standard deviation was lower than 9.8% in all case. 
      The proposed analytical method has been successfully applied for the analysis of 
      7 synthetic musks in commercial cream.
CI  - (c) 2013 Published by Elsevier B.V.
FAU - Dong, Haifeng
AU  - Dong H
AD  - State Key Laboratory of Chemical Resource Engineering, Beijing University of 
      Chemical Technology, Beijing 100029, China.
FAU - Tang, Hua
AU  - Tang H
AD  - Division of Metrology in Chemistry, National Institute of Metrology, Beijing 
      100013, China.
FAU - Chen, Dazhou
AU  - Chen D
AD  - Division of Metrology in Chemistry, National Institute of Metrology, Beijing 
      100013, China.
FAU - Xu, Ting
AU  - Xu T
AD  - State Key Laboratory of Chemical Resource Engineering, Beijing University of 
      Chemical Technology, Beijing 100029, China.
FAU - Li, Lei
AU  - Li L
AD  - State Key Laboratory of Chemical Resource Engineering, Beijing University of 
      Chemical Technology, Beijing 100029, China. Electronic address: 
      lilei@mail.buct.edu.cn.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131206
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Dinitrobenzenes)
RN  - 0 (Indans)
RN  - 0 (Tetrahydronaphthalenes)
RN  - 0 (Xylenes)
RN  - 145-39-1 (musk tibetine)
RN  - 1Q49IC9FAW (moskene)
RN  - 1ZAO16GU5K (musk xylene)
RN  - 21145-77-7 (acetyl methyl tetramethyl tetralin)
RN  - 483V3E1L6J (musk ketone)
SB  - IM
MH  - Dinitrobenzenes/analysis
MH  - Gas Chromatography-Mass Spectrometry/methods
MH  - Indans/analysis
MH  - Limit of Detection
MH  - Liquid-Liquid Extraction/*methods
MH  - Skin Cream/*chemistry
MH  - Solid Phase Extraction/*methods
MH  - Tandem Mass Spectrometry/*methods
MH  - Tetrahydronaphthalenes/analysis
MH  - Xylenes/analysis
OTO - NOTNLM
OT  - Cream
OT  - GC-MS/MS
OT  - SLE
OT  - SPE
OT  - Synthetic musks
EDAT- 2014/01/29 06:00
MHDA- 2014/09/23 06:00
CRDT- 2014/01/29 06:00
PHST- 2013/10/15 00:00 [received]
PHST- 2013/11/27 00:00 [revised]
PHST- 2013/11/29 00:00 [accepted]
PHST- 2014/01/29 06:00 [entrez]
PHST- 2014/01/29 06:00 [pubmed]
PHST- 2014/09/23 06:00 [medline]
AID - S0039-9140(13)00974-0 [pii]
AID - 10.1016/j.talanta.2013.11.086 [doi]
PST - ppublish
SO  - Talanta. 2014 Mar;120:248-54. doi: 10.1016/j.talanta.2013.11.086. Epub 2013 Dec 
      6.