PMID- 24468545
OWN - NLM
STAT- MEDLINE
DCOM- 20141203
LR  - 20220410
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 110
DP  - 2014 Apr
TI  - BDNF and COMT polymorphisms have a limited association with episodic memory 
      performance or engagement in complex cognitive activity in healthy older adults.
PG  - 1-7
LID - S1074-7427(14)00014-8 [pii]
LID - 10.1016/j.nlm.2014.01.013 [doi]
AB  - Cognitive decline is a major factor in lowering the quality of life in older 
      populations, and contributes substantially to social, economic, and health costs. 
      As humans age, cognitive function decreases differentially, and individual 
      differences in cognitive ageing are likely attributed to a range of causes, 
      including environmental and genetic influences. The current study included 360 
      participants (240 females and 120 males) aged between 50 and 79years from the 
      Tasmanian Healthy Brain Project. The brain-derived neurotrophic factor (BDNF) 
      Val66Met and Catechol-O-Methyltransferase (COMT) Val158Met polymorphisms were 
      examined for their association with visual and auditory episodic memory 
      performance. The polymorphisms were also investigated for their association with 
      reported life-long engagement in complex cognitive activity using a retrospective 
      questionnaire. Relative to the demographic variables, the gene variations were 
      found to have no association with episodic memory performance, with the exception 
      of the COMT polymorphism on a single measure of auditory memory (RAVLT). Several 
      other studies also demonstrated that these polymorphisms have no, small, or 
      inconsistent effects on memory function. The BDNF Val66Met and COMT Val158Met 
      polymorphisms were also found to be of little significance to active engagement 
      in complex cognitive activity throughout most of the lifespan. An association was 
      detected between BDNF Val66Met and engagement in cognitive activity in early life 
      (p=.04, d=.23), however this did not reach significance when adjusted for 
      multiple comparisons. The biological mechanisms that underlie engagement in 
      cognitive activity are elusive, thus the potential relationship between BDNF 
      Val66Met genotype and early life cognitive engagement warrants further 
      investigation.
CI  - Crown Copyright (c) 2014. Published by Elsevier Inc. All rights reserved.
FAU - Stuart, Kimberley
AU  - Stuart K
AD  - Wicking Dementia Research and Education Centre, University of Tasmania, 
      Australia; School of Medicine, University of Tasmania, Tasmania, Australia.
FAU - Summers, Mathew James
AU  - Summers MJ
AD  - Wicking Dementia Research and Education Centre, University of Tasmania, 
      Australia; School of Psychology, University of Tasmania, Tasmania, Australia. 
      Electronic address: Mathew.Summers@utas.edu.au.
FAU - Valenzuela, Michael J
AU  - Valenzuela MJ
AD  - Regenerative Neuroscience Group, Brain and Mind Research Institute, University of 
      Sydney, Australia.
FAU - Vickers, James C
AU  - Vickers JC
AD  - Wicking Dementia Research and Education Centre, University of Tasmania, 
      Australia; School of Medicine, University of Tasmania, Tasmania, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140124
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.1.1.6 (COMT protein, human)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
SB  - IM
MH  - Aged
MH  - Aging/psychology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Catechol O-Methyltransferase/*genetics
MH  - Cognition/*physiology
MH  - Female
MH  - Genetic Association Studies
MH  - Genotype
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - *Memory, Episodic
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Prospective Studies
OTO - NOTNLM
OT  - Ageing
OT  - BDNF
OT  - COMT
OT  - Cognition
OT  - LEQ
OT  - Memory
EDAT- 2014/01/29 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/29 06:00
PHST- 2013/10/09 00:00 [received]
PHST- 2014/01/15 00:00 [revised]
PHST- 2014/01/19 00:00 [accepted]
PHST- 2014/01/29 06:00 [entrez]
PHST- 2014/01/29 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - S1074-7427(14)00014-8 [pii]
AID - 10.1016/j.nlm.2014.01.013 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2014 Apr;110:1-7. doi: 10.1016/j.nlm.2014.01.013. Epub 2014 
      Jan 24.