PMID- 24468644
OWN - NLM
STAT- MEDLINE
DCOM- 20141125
LR  - 20221207
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 51
DP  - 2014 Jun 3
TI  - The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor 
      levels in Han Chinese patients with bipolar disorder and schizophrenia.
PG  - 99-104
LID - S0278-5846(14)00013-X [pii]
LID - 10.1016/j.pnpbp.2014.01.012 [doi]
AB  - OBJECTIVE: Brain-derived neurotropic factor (BDNF) is widely distributed in the 
      peripheral and central nervous systems. BDNF and its gene polymorphism may be 
      important in synaptic plasticity and neuron survival, and may become a key target 
      in the physiopathology of several mental illnesses. To elucidate the role of 
      BDNF, we compared the plasma BDNF levels and the BDNF Val66Met gene variants 
      effect in several mental disorders. METHOD: We enrolled 644 participants: 177 
      patients with bipolar I disorder (BP-I), 190 with bipolar II disorder (BP-II), 
      151 with schizophrenia, and 126 healthy controls. Their plasma BDNF levels and 
      BDNF Val66Met single nucleotide polymorphisms (SNP) were checked before 
      pharmacological treatment. RESULTS: Plasma levels of BDNF were significantly 
      lower in patients with schizophrenia than in healthy controls and patients with 
      bipolar disorder (F = 37.667, p<0.001); the distribution of the BDNF Val66Met SNP 
      was not different between groups (chi(2) = 5.289, p = 0.507). Nor were plasma BDNF 
      levels significantly different between Met/Met, Met/Val, and Val/Val carriers in 
      each group, which indicated that the BDNF Val66Met SNP did not influence plasma 
      BDNF levels in our participants. Plasma BDNF levels were, however, significantly 
      negatively correlated with depression scores in patients with bipolar disorder 
      and with negative symptoms in patients with schizophrenia. CONCLUSION: We 
      conclude that plasma BDNF profiles in different mental disorders are not affected 
      by BDNF Val66Met gene variants, but by the process and progression of the illness 
      itself.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Chen, Shiou-Lan
AU  - Chen SL
AD  - Department of Neurology, School of Medicine, Kaohsiung Medical University, 
      Kaohsiung, Taiwan; Department of Psychiatry, National Cheng Kung University, 
      Taiwan. Electronic address: shioulan@mail.ncku.edu.tw.
FAU - Lee, Sheng-Yu
AU  - Lee SY
AD  - Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng 
      Kung University Hospital, Taiwan; Addiction Research Center, National Cheng Kung 
      University, Taiwan.
FAU - Chang, Yun-Hsuan
AU  - Chang YH
AD  - Department of Psychiatry, National Cheng Kung University, Taiwan; Institute of 
      Allied Health Sciences, College of Medicine, National Cheng Kung University, 
      Taiwan.
FAU - Chen, Shih-Heng
AU  - Chen SH
AD  - Department of Psychiatry, National Cheng Kung University, Taiwan; 
      Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National 
      Institute of Environmental Health Sciences/National Institutes of Health, 
      Research Triangle Park, NC, USA.
FAU - Chu, Chun-Hsien
AU  - Chu CH
AD  - Department of Psychiatry, National Cheng Kung University, Taiwan; 
      Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National 
      Institute of Environmental Health Sciences/National Institutes of Health, 
      Research Triangle Park, NC, USA.
FAU - Wang, Tzu-Yun
AU  - Wang TY
AD  - Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng 
      Kung University Hospital, Taiwan.
FAU - Chen, Po-See
AU  - Chen PS
AD  - Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng 
      Kung University Hospital, Taiwan; Addiction Research Center, National Cheng Kung 
      University, Taiwan.
FAU - Lee, I-Hui
AU  - Lee IH
AD  - Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng 
      Kung University Hospital, Taiwan; Addiction Research Center, National Cheng Kung 
      University, Taiwan.
FAU - Yang, Yen-Kuang
AU  - Yang YK
AD  - Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng 
      Kung University Hospital, Taiwan; Addiction Research Center, National Cheng Kung 
      University, Taiwan.
FAU - Hong, Jau-Shyong
AU  - Hong JS
AD  - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National 
      Institute of Environmental Health Sciences/National Institutes of Health, 
      Research Triangle Park, NC, USA.
FAU - Lu, Ru-Band
AU  - Lu RB
AD  - Department of Psychiatry, National Cheng Kung University, Taiwan; National Cheng 
      Kung University Hospital, Taiwan; Institute of Allied Health Sciences, College of 
      Medicine, National Cheng Kung University, Taiwan; Addiction Research Center, 
      National Cheng Kung University, Taiwan; Institute of Behavior Medicine, National 
      Cheng Kung University, Taiwan; Center for Neuropsychiatric Research, National 
      Health Research Institutes, Taiwan. Electronic address: rblu@mail.ncku.edu.tw.
LA  - eng
GR  - Z01 ES090082/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140125
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Asian People/ethnology/genetics
MH  - Bipolar Disorder/blood/ethnology/*genetics
MH  - Brain-Derived Neurotrophic Factor/*blood/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Schizophrenia/blood/ethnology/*genetics
MH  - Valine/genetics
MH  - Young Adult
PMC - PMC7137229
MID - NIHMS1566928
OTO - NOTNLM
OT  - BDNF Val66Met gene
OT  - Bipolar disorders
OT  - Plasma BDNF
OT  - Schizophrenia
COIS- Conflict of interest All of the authors declared no conflicts of interest.
EDAT- 2014/01/29 06:00
MHDA- 2014/12/15 06:00
PMCR- 2020/04/06
CRDT- 2014/01/29 06:00
PHST- 2013/09/03 00:00 [received]
PHST- 2014/01/07 00:00 [revised]
PHST- 2014/01/19 00:00 [accepted]
PHST- 2014/01/29 06:00 [entrez]
PHST- 2014/01/29 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2020/04/06 00:00 [pmc-release]
AID - S0278-5846(14)00013-X [pii]
AID - 10.1016/j.pnpbp.2014.01.012 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:99-104. doi: 
      10.1016/j.pnpbp.2014.01.012. Epub 2014 Jan 25.