PMID- 24469614
OWN - NLM
STAT- MEDLINE
DCOM- 20140623
LR  - 20150430
IS  - 1572-0241 (Electronic)
IS  - 0002-9270 (Linking)
VI  - 109
IP  - 5
DP  - 2014 May
TI  - Prospective evaluation of adverse events following lower gastrointestinal tract 
      EUS FNA.
PG  - 676-85
LID - 10.1038/ajg.2013.479 [doi]
AB  - OBJECTIVES: There are virtually no data concerning the risk of adverse events 
      (AEs) following lower gastrointestinal (LGI) endoscopic ultrasound (EUS). Our aim 
      was to determine the incidence and factors associated with AEs following LGI EUS 
      fine needle aspiration (FNA). METHODS: We conducted a prospective cohort study at 
      a tertiary referral center. Five hundred and sixty-three patients underwent LGI 
      EUS FNA between 1 January 2004 and 1 January 2012. We analyzed the 502 patients 
      who had complete follow-up. AE severity was graded (1-5) utilizing Common 
      Terminology Criteria or Visual Analog Scale. AEs were assessed during the 
      procedures, in clinical follow-up, during phone interviews conducted at 7-14 
      days, and final clinical and/or phone interviews at 2-4 months. RESULTS: AEs 
      developed in 103 (20.5%) patients and were classified as grade 1, 2, 3, or 4 in 
      34 (6.8%), 41 (8.2%), 23 (4.6%), and 5 (1.0%) patients, respectively. Bleeding 
      and pain were the commonest AEs. No deaths occurred. On multivariate analysis, 
      AEs were associated with prior pain (odds ratio (OR): 3.83, 95% confidence 
      interval (CI): 2.35-6.25), FNA from a site other than a lymph node (LN) or gut 
      wall (OR: 2.26, 95% CI: 1.10-4.70), and malignant FNA cytology (OR: 1.80, 95% CI: 
      1.10-2.97); serious (grade 3-4) AEs were associated with prior pain (OR: 15.21, 
      95% CI: 5.04-45.85) and FNA from a site other than a LN or gut wall (OR: 3.25, 
      95% CI: 1.15-9.20). CONCLUSIONS: LGI EUS FNA is associated with a high rate of 
      serious grades 3-4 AEs. This may reflect the total number of associated 
      interventions and the frequency of underlying pathology and symptoms.
FAU - Levy, Michael J
AU  - Levy MJ
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, 
      USA.
FAU - Abu Dayyeh, Barham K
AU  - Abu Dayyeh BK
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, 
      USA.
FAU - Fujii, Larissa L
AU  - Fujii LL
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, 
      USA.
FAU - Boardman, Lisa A
AU  - Boardman LA
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, 
      USA.
FAU - Clain, Jonathan E
AU  - Clain JE
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, 
      USA.
FAU - Iyer, Prasad G
AU  - Iyer PG
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, 
      USA.
FAU - Rajan, Elizabeth
AU  - Rajan E
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, 
      USA.
FAU - Topazian, Mark D
AU  - Topazian MD
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, 
      USA.
FAU - Wang, Kenneth K
AU  - Wang KK
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, 
      USA.
FAU - Wiersema, Maurits J
AU  - Wiersema MJ
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, 
      USA.
FAU - Gleeson, Ferga C
AU  - Gleeson FC
AD  - Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, 
      USA.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20140128
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Colon/*pathology
MH  - Colonic Diseases/epidemiology/etiology
MH  - Colonoscopy
MH  - Endoscopic Ultrasound-Guided Fine Needle Aspiration/*adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Gastrointestinal Hemorrhage/epidemiology/etiology
MH  - Humans
MH  - Hypotension/epidemiology/etiology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Pain/epidemiology/etiology
MH  - Prospective Studies
MH  - Rectal Diseases/epidemiology/etiology
MH  - Rectum/*pathology
MH  - Risk Factors
MH  - Young Adult
EDAT- 2014/01/29 06:00
MHDA- 2014/06/24 06:00
CRDT- 2014/01/29 06:00
PHST- 2013/09/27 00:00 [received]
PHST- 2013/12/16 00:00 [accepted]
PHST- 2014/01/29 06:00 [entrez]
PHST- 2014/01/29 06:00 [pubmed]
PHST- 2014/06/24 06:00 [medline]
AID - ajg2013479 [pii]
AID - 10.1038/ajg.2013.479 [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2014 May;109(5):676-85. doi: 10.1038/ajg.2013.479. Epub 2014 
      Jan 28.