PMID- 24469773
OWN - NLM
STAT- MEDLINE
DCOM- 20150622
LR  - 20211021
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 22
IP  - 3
DP  - 2015 Feb
TI  - Assessment of association between the dopamine D2 receptor (DRD2) polymorphism 
      and neurodevelopment of children exposed to lead.
PG  - 1786-93
LID - 10.1007/s11356-014-2565-9 [doi]
AB  - The mechanism of lead (Pb) neurotoxicity has not been illustrated over the years. 
      People pay more attention to dopaminergic neurotransmission, specifically 
      dopamine receptor-2 (DRD2) Taq IA polymorphism, but no consensus has been 
      reached. A total of 258 three-year-old children in Guiyu (exposed group) and 
      Nanao (reference group), China were examined and their concentrations of blood 
      lead (BPb) were determined. Cognitive and language scores of children were 
      assessed using the Bayley Scales of Infant Development, third edition (BSID-III). 
      Genotyping for the DRD2 polymorphism was carried out using a polymerase chain 
      reaction (PCR) re-sequencing platform. The logistic stepwise regression analysis 
      and stepwise regression analysis was used to explore associations among lead, 
      neurodevelopment of children, and DRD2 Taq IA categories. Median values of Pb in 
      Guiyu was higher than that of the reference group (11.30 +/- 5.38 mug/dL vs. 
      5.77 +/- 2.51 mug/dL, P < 0.001). Compared with the reference group, children from 
      e-waste exposed area have lower cognitive scale scores (100 +/- 25 vs 120 +/- 20, 
      P < 0.001) and lower language scale scores (99.87 +/- 7.52 vs 111.39 +/- 7.02, 
      P < 0.001). The three kinds of genotype, A1/A1, A1/A2, and A2/A2, had no 
      significant influences on BPb, cognitive scores and language scores (P > 0.05). 
      Exposure of inhabitants, especially children to Pb from informal e-waste 
      recycling activities might have contributed to higher levels of BPb and reduced 
      cognitive and language scores observed in local children, however, the result 
      obtained showed no significant association between DRD2 polymorphism and 
      neurodevelopment of children exposed to lead.
FAU - Liu, Lian
AU  - Liu L
AD  - Laboratory of Environmental Medicine and Developmental Toxicology, and Provincial 
      Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou 
      University Medical College, Shantou, 515041, Guangdong, People's Republic of 
      China.
FAU - Xu, Xijin
AU  - Xu X
FAU - Yekeen, Taofeek Akangbe
AU  - Yekeen TA
FAU - Lin, Kun
AU  - Lin K
FAU - Li, Weiqiu
AU  - Li W
FAU - Huo, Xia
AU  - Huo X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140128
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Environmental Pollutants)
RN  - 0 (Receptors, Dopamine D2)
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Child Development/drug effects
MH  - Child, Preschool
MH  - China
MH  - Cognition
MH  - *Electronic Waste
MH  - Environmental Exposure/*analysis
MH  - Environmental Pollutants/*blood
MH  - Genotype
MH  - Humans
MH  - Language
MH  - Lead/*blood
MH  - Polymorphism, Genetic
MH  - Receptors, Dopamine D2/*genetics
MH  - Recycling
EDAT- 2014/01/29 06:00
MHDA- 2015/06/24 06:00
CRDT- 2014/01/29 06:00
PHST- 2013/11/08 00:00 [received]
PHST- 2014/01/16 00:00 [accepted]
PHST- 2014/01/29 06:00 [entrez]
PHST- 2014/01/29 06:00 [pubmed]
PHST- 2015/06/24 06:00 [medline]
AID - 10.1007/s11356-014-2565-9 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2015 Feb;22(3):1786-93. doi: 
      10.1007/s11356-014-2565-9. Epub 2014 Jan 28.