PMID- 24470282
OWN - NLM
STAT- MEDLINE
DCOM- 20150223
LR  - 20220321
IS  - 1532-2807 (Electronic)
IS  - 1219-4956 (Linking)
VI  - 20
IP  - 3
DP  - 2014 Jul
TI  - Prognostic significance of cyclin D1 and E-cadherin expression in laryngeal 
      squamous cell carcinoma.
PG  - 625-33
LID - 10.1007/s12253-014-9741-6 [doi]
AB  - Cyclin D1 and E-cadherin are important factors in the progression and metastasis 
      of cancers. Their role in laryngeal carcinoma has been studied with conflicting 
      results. To define the frequency of cyclin D1 and E-cadherin expression and its 
      correlation with both the clinicopathological characteristics and prognosis of 
      patients with laryngeal squamous cell carcinoma (LSCC). Tumor tissue samples from 
      75 patients with laryngeal squamous cell carcinoma were examined for cyclin D1 
      and E-cadherin expression by immunohistochemistry. The relationship between the 
      expression of both molecules and the age and sex of the patient, tumor site, 
      tumor differentiation, lymph node metastasis, tumor invasiveness, TNM stages, 
      tumor recurrence and overall survival was analyzed. Cyclin D1 was found to be a 
      significant independent prognostic factor of lymph node metastasis (p = 0.000). 
      The multivariate analysis revealed that cyclin D1 and E-cadherin expression 
      wasn't an independent prognostic factor of local recurrence free survival (LRFS) 
      in patients with LSCC (P = 0.56 and 0.28) respectively. However, the univariate 
      analysis revealed a significant association between them and LRFS (p = 0.003 and 
      0.000) respectively. Also, the group of high cyclin D1 /low E-cadherin expression 
      had the poorest prognosis, so they might serve as potential predictors of the 
      prognosis of the patients with LSCC. E-cadherin was found to affect the overall 
      survival (OAS) significantly by the univariate analysis (p = 0.01). However, by 
      the multivariate analysis the TNM stage was the only independent prognostic 
      factor of OAS (p < 0.05). Cyclin D1 can be used as an independent prognostic 
      marker of lymph node metastasis in patients with LSCC and can help to identify 
      those patients with clinically negative lymph nodes but with considerable risk 
      for occult metastasis. Detection of cyclin D1 and E-cadherin status in LSCC may 
      contribute to the identification of patients with high risk factors of local 
      recurrence. However, they don't appear to be better prognostic predictors than 
      other established markers in LSCC.
FAU - Ahmed, Rehab Allah
AU  - Ahmed RA
AD  - Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
FAU - Shawky, Abd El-Aty
AU  - Shawky Ael-A
FAU - Hamed, Rasha Hamdy
AU  - Hamed RH
LA  - eng
PT  - Journal Article
DEP - 20140129
PL  - Switzerland
TA  - Pathol Oncol Res
JT  - Pathology oncology research : POR
JID - 9706087
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (CCND1 protein, human)
RN  - 0 (Cadherins)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*metabolism
MH  - Cadherins/*metabolism
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/secondary
MH  - Cyclin D1/*metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Survival Rate
EDAT- 2014/01/29 06:00
MHDA- 2015/02/24 06:00
CRDT- 2014/01/29 06:00
PHST- 2013/03/12 00:00 [received]
PHST- 2014/01/03 00:00 [accepted]
PHST- 2014/01/29 06:00 [entrez]
PHST- 2014/01/29 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - 10.1007/s12253-014-9741-6 [doi]
PST - ppublish
SO  - Pathol Oncol Res. 2014 Jul;20(3):625-33. doi: 10.1007/s12253-014-9741-6. Epub 
      2014 Jan 29.