PMID- 24470873
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140128
LR  - 20211021
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 16
IP  - 3
DP  - 2013 Mar
TI  - Association of IL-10 Gene Polymorphisms and Human T Lymphotropic Virus Type 
      I-Associated Myelopathy/tropical Spastic Paraparesis in North-East of Iran 
      (Mashhad).
PG  - 258-63
AB  - The underlying mechanisms leading to the development of human T-cell lymphotropic 
      virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis 
      (HAM/TSP) in HTLV-I infected individuals are not fully understood. Host genetic 
      factors appear to be involved as risk factors for developing HAM/TSP. We 
      investigated the possible contribution of interleukin-10 (IL-10) as a risk factor 
      to HAM/TSP by comparing frequencies of promoter region single nucleotide 
      polymorphisms in HTLV-I infected Iranian patients who either remained 
      asymptomatic or developed HAM/TSP and asymptomatic HTLV-I carriers. Healthy, 
      uninfected individuals from the same region served as healthy controls. 
      Significant differences were observed in the distribution of IL-10 promoter 
      alleles and genotypes at position -819 and -592 between HAM/TSP patients and 
      healthy controls (P=0.01), and between HTLV-I carriers and healthy controls 
      (P=0.02). The frequency of the low IL-10 producer haplotype (-1082*A, -819*T, 
      -592*A) was significantly associated with HTLV-I carriage or HAM/TSP compared 
      with healthy controls (P=0.02 and 0.01, respectively). Our results suggest that 
      IL-10 -819*T and -592*A alleles are significant risk factors for developing 
      HTLLV-I infection but do not appear to convey additional risk for developing 
      HAM/TSP.
FAU - Shirdel, Abbas
AU  - Shirdel A
AD  - Department of Hematology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Azarpazhooh, Mahmoud Reza
AU  - Azarpazhooh MR
AD  - Neurology Department, School of Medicine, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Sahebari, Maryam
AU  - Sahebari M
AD  - Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Ghanbari, Mohsen
AU  - Ghanbari M
AD  - Immunology Research Centre, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Mirfeizi, Seyedeh Zahra
AU  - Mirfeizi SZ
AD  - Rheumatic Diseases Research Centre, School of Medicine, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
FAU - Hutchinson, Ian
AU  - Hutchinson I
AD  - Immunology Research Group, Faculty of Life Sciences, The University of 
      Manchester, United Kingdom.
FAU - Ziaee, Aghigh
AU  - Ziaee A
AD  - Immunology Research Centre, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
FAU - Rafatpanah, Houshang
AU  - Rafatpanah H
AD  - Inflammation and Inflammatory Disease Research Centre, School of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC3881251
OTO - NOTNLM
OT  - Gene
OT  - HAM/TSP
OT  - HTLV-I
OT  - IL-10
OT  - Polymorphisms
EDAT- 2014/01/29 06:00
MHDA- 2014/01/29 06:01
PMCR- 2013/03/01
CRDT- 2014/01/29 06:00
PHST- 2012/01/13 00:00 [received]
PHST- 2012/06/07 00:00 [accepted]
PHST- 2014/01/29 06:00 [entrez]
PHST- 2014/01/29 06:00 [pubmed]
PHST- 2014/01/29 06:01 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - ijbms-16-258 [pii]
PST - ppublish
SO  - Iran J Basic Med Sci. 2013 Mar;16(3):258-63.