PMID- 24470948
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2036-7430 (Print)
IS  - 2036-7449 (Electronic)
IS  - 2036-7430 (Linking)
VI  - 4
IP  - 2
DP  - 2012 Apr 27
TI  - Predictors of shingles reports at diagnosis of common variable immunodeficiency 
      and selective immunoglobulin G subclass deficiency in 212 Alabama adults.
PG  - e34
LID - 10.4081/idr.2012.e34 [doi]
LID - e34
AB  - We sought to determine predictors of shingles reports in adults with common 
      variable immunodeficiency or immunoglobulin (Ig) G subclass deficiency 
      (CVID/IgGSD). We tabulated observations at diagnosis of CVID/IgGSD in 212 white 
      adult index patients (165 women, 47 men) who responded to a question about having 
      had shingles. None had been vaccinated for herpes zoster. We analyzed age, sex, 
      and shingles reports; blood levels of CD19+, CD4+, CD8+, and CD56+ mononuclear 
      cells; serum levels of IgG subclasses, IgA, and IgM; and positivity for human 
      leukocyte antigen (HLA)-A and -B haplotypes. Cell counts and immunoglobulin 
      levels were normalized with loge (ln) transformation for analyses. Thirty-one 
      patients (14.6%) reported shingles; 11 reported recurrent or disseminated 
      shingles. Patients with shingles reports had greater mean age at diagnosis of 
      CVID/IgGSD [54+/-13 (standard deviation) years vs. 47+/-12 years; P=0.0130] and a 
      greater prevalence of HLA-A*01, B*08 positivity (35.5% vs. 17.7%; P=0.0227). In a 
      13-factor logistic regression model, there was a positive association of age with 
      shingles reports [P=0.0151; odds ratio (1.05, 95% confidence interval 1.01, 
      1.08)]. HLA-A*01, B*08 positivity was also positively associated with shingles 
      reports [P=0.0480; odds ratio 2.61 (1.00, 6.81)]. During a mean followup interval 
      of 7.5 years after CVID/IgGSD diagnosis, the prevalence of recurrent shingles was 
      almost five-fold greater in patients with previous shingles reports. In 
      conclusion, in white adults at CVID/IgGSD diagnosis, age at diagnosis and 
      positivity for HLA-A*01, B*08 have significant positive associations with reports 
      of previous shingles.
FAU - Barton, James C
AU  - Barton JC
AD  - Brookwood Medical Center, ; Southern Iron Disorders Center, ; Department of 
      Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
FAU - Barton, J Clayborn
AU  - Barton JC
AD  - Southern Iron Disorders Center.
FAU - Bertoli, Luigi F
AU  - Bertoli LF
AD  - Brookwood Medical Center, ; Southern Iron Disorders Center.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120719
PL  - Switzerland
TA  - Infect Dis Rep
JT  - Infectious disease reports
JID - 101537203
PMC - PMC3892630
OTO - NOTNLM
OT  - herpes zoster
OT  - human leukocyte antigen
OT  - hypogammaglobulinemia
OT  - immune deficiency.
COIS- Conflict of interests: the authors report no potential conflict of interests.
EDAT- 2012/04/27 00:00
MHDA- 2012/04/27 00:01
PMCR- 2012/07/19
CRDT- 2014/01/29 06:00
PHST- 2011/10/23 00:00 [received]
PHST- 2012/04/16 00:00 [revised]
PHST- 2012/05/28 00:00 [accepted]
PHST- 2014/01/29 06:00 [entrez]
PHST- 2012/04/27 00:00 [pubmed]
PHST- 2012/04/27 00:01 [medline]
PHST- 2012/07/19 00:00 [pmc-release]
AID - idr.2012.e34 [pii]
AID - 10.4081/idr.2012.e34 [doi]
PST - epublish
SO  - Infect Dis Rep. 2012 Jul 19;4(2):e34. doi: 10.4081/idr.2012.e34. eCollection 2012 
      Apr 27.