PMID- 24471327
OWN - NLM
STAT- MEDLINE
DCOM- 20140318
LR  - 20140129
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 38
IP  - 18
DP  - 2013 Sep
TI  - [Impact analysis of shuxuetong injection on abnormal changes of ALT based on 
      generalized boosted models propensity score weighting].
PG  - 3039-47
AB  - OBJECTIVE: To estimate treatment effects of Shuxuetong injection on abnormal 
      changes on ALT index, that is, to explore whether the Shuxuetong injection harms 
      liver function in clinical settings and to provide clinical guidance for its safe 
      application. METHOD: Clinical information of traditional Chinese medicine (TCM) 
      injections is gathered from hospital information system (HIS) of eighteen general 
      hospitals. This is a retrospective cohort study, using abnormal changes in ALT 
      index as an outcome. A large number of confounding biases are taken into account 
      through the generalized boosted models (GBM) and multiple logistic regression 
      model (MLRM) to estimate the treatment effects of Shuxuetong injections on 
      abnormal changes in ALT index and to explore possible influencing factors. 
      RESULT: The advantages and process of application of GBM has been demonstrated 
      with examples which eliminate the biases from most confounding variables between 
      groups. This serves to modify the estimation of treatment effects of Shuxuetong 
      injection on ALT index making the results more reliable. CONCLUSION: Based on 
      large scale clinical observational data from HIS database, significant effects of 
      Shuxuetong injection on abnormal changes in ALT have not been found.
FAU - Yang, Wei
AU  - Yang W
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese 
      Medical Sciences, Beijing 100700, China. yangyxq@ruc.edu.cn
FAU - Yi, Dan-Hui
AU  - Yi DH
AD  - Statistical Institute of Renmin University, Beijing 100872, China.
FAU - Xie, Yan-Ming
AU  - Xie YM
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese 
      Medical Sciences, Beijing 100700, China.
FAU - Yang, Wei
AU  - Yang W
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese 
      Medical Sciences, Beijing 100700, China.
FAU - Dai, Yi
AU  - Dai Y
AD  - Statistical Institute of Renmin University, Beijing 100872, China.
FAU - Zhi, Ying-Jie
AU  - Zhi YJ
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese 
      Medical Sciences, Beijing 100700, China.
FAU - Zhuang, Yan
AU  - Zhuang Y
AD  - The PL4 Navy General Hospital, Beijing 100048, China.
FAU - Yang, Hu
AU  - Yang H
AD  - Statistical Institute of Renmin University, Beijing 100872, China.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (shuxuetong)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alanine Transaminase/*metabolism
MH  - Child
MH  - Drug Therapy
MH  - Drugs, Chinese Herbal/*administration & dosage/adverse effects
MH  - Female
MH  - Hospital Information Systems/statistics & numerical data
MH  - Humans
MH  - Liver/drug effects/enzymology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Pragmatic Clinical Trials as Topic
MH  - Propensity Score
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2014/01/30 06:00
MHDA- 2014/03/19 06:00
CRDT- 2014/01/30 06:00
PHST- 2014/01/30 06:00 [entrez]
PHST- 2014/01/30 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2013 Sep;38(18):3039-47.