PMID- 24472084
OWN - NLM
STAT- MEDLINE
DCOM- 20160422
LR  - 20140422
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 68
IP  - 5
DP  - 2014 May
TI  - Comparison of intramuscular compound betamethasone and oral diclofenac sodium in 
      the treatment of acute attacks of gout.
PG  - 633-8
LID - 10.1111/ijcp.12359 [doi]
AB  - INTRODUCTION: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for 
      the treatment of acute gouty arthritis but have the risk of gastrointestinal 
      bleeding and cardiovascular toxicity. Glucocorticoid was as effective as oral 
      NSAIDs in the initial treatment of gout arthritis of patients intolerant of 
      NSAIDs. However, whether glucocorticoid has the same or preferable effect as oral 
      NSAIDs on patients with acute gouty arthritis irrespective of gastrointestinal 
      and cardiovascular risks factor remains unknown. This study was to compare the 
      efficacy, safety and tolerance of compound betamethasone (diprospan) 7 mg 
      intramuscular injection (i.m.) once for all during the study with diclofenac 
      sodium 75 mg twice a day in the treatment of acute gouty arthritis. METHODS: 
      Sixty patients with acute gouty arthritis were randomised (1 : 1) to receive 
      compound betamethasone 7 mg i.m. once for all during the study or diclofenac 
      sodium 75 mg twice a day for 7 days in this open-label study. Pain intensity, 
      tenderness, swelling and global assessment of response to therapy were collected 
      as end-points for the treatment. RESULTS: The mean change in pain intensity from 
      baseline to Day 3 and Day 7 in both treatment groups demonstrated that compound 
      betamethasone had preferable efficacy over diclofenac sodium on Day 3 and 
      comparable efficacy on Day 7. The compound betamethasone group had fewer adverse 
      effects (AEs) than diclofenac sodium group. No statistically significant 
      differences were observed about serum uric acid levels at different pain 
      intensity at baseline. CONCLUSIONS: A single dose of compound betamethasone may 
      be better than diclofenac sodium for the treatment of acute gouty arthritis.
CI  - (c) 2014 John Wiley & Sons Ltd.
FAU - Zhang, Y-K
AU  - Zhang YK
AD  - Department of Osteology, Qilu Hospital of Shandong University, Jinan, China.
FAU - Yang, H
AU  - Yang H
FAU - Zhang, J-Y
AU  - Zhang JY
FAU - Song, L-J
AU  - Song LJ
FAU - Fan, Y-C
AU  - Fan YC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20140129
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (Gout Suppressants)
RN  - 144O8QL0L1 (Diclofenac)
RN  - 9842X06Q6M (Betamethasone)
SB  - IM
MH  - Acute Disease
MH  - Administration, Oral
MH  - Betamethasone/administration & dosage/adverse effects/*therapeutic use
MH  - Diclofenac/administration & dosage/adverse effects/*therapeutic use
MH  - Female
MH  - Gout/*drug therapy
MH  - Gout Suppressants/administration & dosage/adverse effects/*therapeutic use
MH  - Humans
MH  - Injections, Intramuscular
MH  - Male
MH  - Middle Aged
EDAT- 2014/01/30 06:00
MHDA- 2016/04/23 06:00
CRDT- 2014/01/30 06:00
PHST- 2014/01/30 06:00 [entrez]
PHST- 2014/01/30 06:00 [pubmed]
PHST- 2016/04/23 06:00 [medline]
AID - 10.1111/ijcp.12359 [doi]
PST - ppublish
SO  - Int J Clin Pract. 2014 May;68(5):633-8. doi: 10.1111/ijcp.12359. Epub 2014 Jan 
      29.