PMID- 24473442 OWN - NLM STAT- MEDLINE DCOM- 20150306 LR - 20211021 IS - 2158-3188 (Electronic) IS - 2158-3188 (Linking) VI - 4 IP - 1 DP - 2014 Jan 28 TI - Social interaction plays a critical role in neurogenesis and recovery after stroke. PG - e351 LID - 10.1038/tp.2013.128 [doi] AB - Stroke survivors often experience social isolation. Social interaction improves quality of life and decreases mortality after stroke. Male mice (20-25 g; C57BL/6N), all initially pair housed, were subjected to middle cerebral artery occlusion (MCAO). Mice were subsequently assigned into one of three housing conditions: (1) Isolated (SI); (2) Paired with their original cage mate who was also subjected to stroke (stroke partner (PH-SP)); or (3) Paired with their original cage mate who underwent sham surgery (healthy partner (PH-HP)). Infarct analysis was performed 72 h after stroke and chronic survival was assessed at day 30. Immediate post-stroke isolation led to a significant increase in infarct size and mortality. Interestingly, mice paired with a healthy partner had significantly lower mortality than mice paired with a stroke partner, despite equivalent infarct damage. To control for changes in infarct size induced by immediate post-stroke isolation, additional cohorts were assessed that remained pair housed for three days after stroke prior to randomization. Levels of brain-derived neurotrophic factor (BDNF) were assessed at 90 days and cell proliferation (in cohorts injected with 5-bromo-2'-deoxyuridine, BrdU) was evaluated at 8 and 90 days after stroke. All mice in the delayed housing protocol had equivalent infarct volumes (SI, PH-HP and PH-SP). Mice paired with a healthy partner showed enhanced behavioral recovery compared with either isolated mice or mice paired with a stroke partner. Behavioral improvements paralleled changes in BDNF levels and neurogenesis. These findings suggest that the social environment has an important role in recovery after ischemic brain injury. FAU - Venna, V R AU - Venna VR AD - Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA. FAU - Xu, Y AU - Xu Y AD - Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA. FAU - Doran, S J AU - Doran SJ AD - Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA. FAU - Patrizz, A AU - Patrizz A AD - Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA. FAU - McCullough, L D AU - McCullough LD AD - 1] Department of Neuroscience, University of Connecticut Health Center, Farmington, CT, USA [2] Department of Neurology, University of Connecticut Health Center, Farmington, CT, USA [3] The Stroke Center at Hartford Hospital, Hartford, CT, USA. LA - eng GR - R01 NSO77769/PHS HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20140128 PL - United States TA - Transl Psychiatry JT - Translational psychiatry JID - 101562664 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Animals MH - Behavior, Animal/*physiology MH - Brain-Derived Neurotrophic Factor/metabolism MH - Hippocampus/metabolism MH - Infarction, Middle Cerebral Artery/complications/pathology/*rehabilitation MH - *Interpersonal Relations MH - Male MH - Mice MH - Mice, Inbred C57BL MH - Neurogenesis/*physiology MH - Random Allocation MH - Recovery of Function/physiology MH - *Social Isolation PMC - PMC3905235 EDAT- 2014/01/30 06:00 MHDA- 2015/03/07 06:00 PMCR- 2014/01/01 CRDT- 2014/01/30 06:00 PHST- 2013/09/13 00:00 [received] PHST- 2013/11/25 00:00 [revised] PHST- 2013/12/07 00:00 [accepted] PHST- 2014/01/30 06:00 [entrez] PHST- 2014/01/30 06:00 [pubmed] PHST- 2015/03/07 06:00 [medline] PHST- 2014/01/01 00:00 [pmc-release] AID - tp2013128 [pii] AID - 10.1038/tp.2013.128 [doi] PST - epublish SO - Transl Psychiatry. 2014 Jan 28;4(1):e351. doi: 10.1038/tp.2013.128.