PMID- 24474274
OWN - NLM
STAT- MEDLINE
DCOM- 20140506
LR  - 20140305
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 55
IP  - 3
DP  - 2014 Mar 4
TI  - Subfoveal choroidal thickness and cerebrospinal fluid pressure: the Beijing Eye 
      Study 2011.
PG  - 1292-8
LID - 10.1167/iovs.13-13351 [doi]
AB  - PURPOSE: The venous choroidal blood drains through the superior orbital vein into 
      the intracranial cavernous sinus. The cerebrospinal fluid pressure (CSFP) may 
      thus influence the choroidal venous blood pressure. Since volume and thickness of 
      the choroid depend on its pressure, we tested the hypothesis whether the 
      subfoveal choroidal thickness (SFCT) is associated with CSFP. METHODS: The 
      population-based Beijing Eye Study 2011 included 3468 individuals. A detailed 
      ophthalmic examination was performed including spectral-domain optical coherence 
      tomography (SD-OCT) with enhanced depth imaging for measurement of SFCT. The CSFP 
      was calculated as CSFP (mm Hg) = 0.44 x Body Mass Index (kg/m(2)) + 0.16 x 
      Diastolic Blood Pressure (mm Hg) - 0.18 x Age (years) - 1.91. RESULTS: Mean 
      calculated CSFP was 8.8 +/- 3.7 mm Hg and mean SFCT was 254 +/- 107 mum. In 
      multivariate analysis, SFCT was significantly associated with higher CSFP (P = 
      0.009; standardized coefficient beta: 0.08; regression coefficient B: 2.27) after 
      adjusting for lower age (P < 0.001; beta: -0.36; B: -3.99), shorter axial length (P 
      < 0.001; beta: -0.37; B: -35.7), lower body mass index (P = 0.02; beta: -0.05; B: 
      -1.51), and higher corneal curvature radius (P < 0.001; beta: 0.10; B: 41.1). In 
      univariate analysis, SFCT increased by 9.2 mum (95% confidence interval: 8.3, 
      10.1) for each mm Hg increase in CSFP. In a reverse manner, CSFP was 
      significantly associated with thicker SFCT (P < 0.001; B: 0.007; beta: 0.21), after 
      adjusting for region of habitation (P < 0.001; B: -0.31; beta: -2.32), higher levels 
      of glucose (P = 0.02; B: 0.10; beta: 0.04) and triglycerides (P < 0.001; B: 0.13; beta: 
      0.09), higher intraocular pressure (P < 0.001; B: 0.17; beta: 0.12), and thinner 
      lens (P < 0.001; B: -2.39; beta: -0.22). CONCLUSIONS: Thicker subfoveal choroid was 
      associated with higher CSFP after adjustment for age, axial length, body mass 
      index, and corneal curvature radius. This association may explain thicker SFCT 
      measurements in the morning than evening. It shows the importance of the CSFP for 
      the physiology of the eye.
FAU - Jonas, Jost B
AU  - Jonas JB
AD  - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren 
      Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science 
      Key Lab, Beijing, China.
FAU - Wang, Ningli
AU  - Wang N
FAU - Wang, Ya Xing
AU  - Wang YX
FAU - You, Qi Sheng
AU  - You QS
FAU - Yang, Diya
AU  - Yang D
FAU - Xie, Xiaobin
AU  - Xie X
FAU - Wei, Wen Bin
AU  - Wei WB
FAU - Xu, Liang
AU  - Xu L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140304
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/physiology
MH  - Cerebrospinal Fluid Pressure/*physiology
MH  - Choroid/*cytology
MH  - Circadian Rhythm
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Population Surveillance
MH  - Tomography, Optical Coherence/methods
OTO - NOTNLM
OT  - Beijing Eye Study
OT  - axial length
OT  - cerebrospinal fluid pressure
OT  - subfoveal choroidal thickness
OT  - translamina cribrosa pressure difference
EDAT- 2014/01/30 06:00
MHDA- 2014/05/07 06:00
CRDT- 2014/01/30 06:00
PHST- 2014/01/30 06:00 [entrez]
PHST- 2014/01/30 06:00 [pubmed]
PHST- 2014/05/07 06:00 [medline]
AID - iovs.13-13351 [pii]
AID - 10.1167/iovs.13-13351 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2014 Mar 4;55(3):1292-8. doi: 10.1167/iovs.13-13351.