PMID- 24474280
OWN - NLM
STAT- MEDLINE
DCOM- 20140414
LR  - 20140221
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 55
IP  - 2
DP  - 2014 Feb 20
TI  - Effect of acute intraocular pressure challenge on rat retinal and cortical 
      function.
PG  - 1067-77
LID - 10.1167/iovs.13-13003 [doi]
AB  - PURPOSE: The global or gross response index of visual performance measured from 
      the eye does not necessarily translate to global responses measured from the 
      brain. A better understanding of this relationship would facilitate the 
      monitoring of disease models that affect the visual pathway. We consider whether 
      rod- and cone-retino-cortical-pathways are equally affected by acute IOP 
      elevation. METHODS: Acute, stepwise IOP elevation (10, 30, 40, 50, 60, 70 mm Hg) 
      was induced in anesthetized dark- (N = 8) and light-adapted pigmented rats (N = 
      6). Electroretinogram (ERG) and visual evoked potentials (VEP) were 
      simultaneously measured after 10 minutes at each step. Relative amplitudes 
      (treated/baseline, %) as a function of IOP level were described with a cumulative 
      normal function. RESULTS: Our results showed decline in scotopic and photopic 
      ERGs with IOP elevation. Photopic ERG responses were less sensitive to IOP 
      challenge than scotopic ERG responses. Despite significant reductions of ganglion 
      cell-mediated waveforms at 70 mm Hg, the VEP showed only subtle decreases in 
      amplitude. Intraocular pressure elevation produced similar effects on rod- and 
      cone-mediated VEP waveforms. CONCLUSIONS: We show that cone signals are less 
      sensitive than rod ERGs to acute IOP challenge. Also, retinal signals are more 
      sensitive than are cortical signals to IOP stress, suggesting that cortical 
      processing may act to salvage reductions expected from attenuated retinal output.
FAU - Tsai, Tina I
AU  - Tsai TI
AD  - Department of Optometry and Vision Sciences, University of Melbourne, Victoria, 
      Australia.
FAU - Bui, Bang V
AU  - Bui BV
FAU - Vingrys, Algis J
AU  - Vingrys AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140220
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Animals
MH  - Color Vision/physiology
MH  - Dark Adaptation/physiology
MH  - *Electroretinography
MH  - Evoked Potentials, Visual/*physiology
MH  - *Intraocular Pressure/physiology
MH  - Night Vision/physiology
MH  - Ocular Hypertension/*physiopathology
MH  - Photic Stimulation
MH  - Rats
MH  - Rats, Long-Evans
MH  - Retina/*physiopathology
MH  - Visual Cortex/*physiopathology
OTO - NOTNLM
OT  - IOP
OT  - electroretinogram
OT  - rat
OT  - visual evoked potential
EDAT- 2014/01/30 06:00
MHDA- 2014/04/15 06:00
CRDT- 2014/01/30 06:00
PHST- 2014/01/30 06:00 [entrez]
PHST- 2014/01/30 06:00 [pubmed]
PHST- 2014/04/15 06:00 [medline]
AID - iovs.13-13003 [pii]
AID - 10.1167/iovs.13-13003 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2014 Feb 20;55(2):1067-77. doi: 10.1167/iovs.13-13003.