PMID- 24475405
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 2251-8363 (Print)
IS  - 2251-8819 (Electronic)
IS  - 2251-8363 (Linking)
VI  - 1
IP  - 3
DP  - 2012 Oct
TI  - ACE insertion/deletion (I/D) polymorphism and diabetic nephropathy.
PG  - 143-51
LID - 10.5812/nephropathol.8109 [doi]
AB  - CONTEXT: Angiotensin converting enzyme (ACE) gene encodes ACE, a key component of 
      renin angiotensin system (RAS), plays an important role in blood pressure 
      homeostasis by generating the vasoconstrictor peptide angiotensin II. EVIDENCE 
      ACQUISITIONS: Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed 
      (NLM), LISTA (EBSCO) and Web of Science have been searched. RESULTS: The presence 
      of ACE insertion/deletion (I/D) polymorphism affects the plasma level of ACE. ACE 
      DD genotype is associated with the highest systemic and renal ACE levels compared 
      with the lowest ACE activity in carriers of II genotype. CONCLUSIONS: In this 
      review focus has been performed on the study of ACE I/D polymorphism in various 
      populations and its influence on the risk of onset and progression of diabetic 
      nephropathy. Also, association between ACE I/D polymorphism and response to ACE 
      inhibitor and angiotensin II receptor antagonists will be reviewed. Further, 
      synergistic effect of this polymorphism and variants of some genes on the risk of 
      development of diabetic nephropathy will be discussed.
FAU - Rahimi, Zohreh
AU  - Rahimi Z
AD  - Medical Biology Research Center and Department of Biochemistry, Kermanshah 
      University of Medical Sciences, Kermanshah, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121001
PL  - Iran
TA  - J Nephropathol
JT  - Journal of nephropathology
JID - 101611182
PMC - PMC3886156
OTO - NOTNLM
OT  - ACE I/D polymorphism
OT  - ACE activity
OT  - ACE inhibitors
OT  - Angiotensin II receptor blockers
OT  - Diabetic nephropathy
EDAT- 2012/10/01 00:00
MHDA- 2012/10/01 00:01
PMCR- 2012/10/01
CRDT- 2014/01/30 06:00
PHST- 2012/08/02 00:00 [received]
PHST- 2012/08/12 00:00 [accepted]
PHST- 2014/01/30 06:00 [entrez]
PHST- 2012/10/01 00:00 [pubmed]
PHST- 2012/10/01 00:01 [medline]
PHST- 2012/10/01 00:00 [pmc-release]
AID - 10.5812/nephropathol.8109 [doi]
PST - ppublish
SO  - J Nephropathol. 2012 Oct;1(3):143-51. doi: 10.5812/nephropathol.8109. Epub 2012 
      Oct 1.