PMID- 24475422
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20240109
IS  - 2251-8363 (Print)
IS  - 2251-8819 (Electronic)
IS  - 2251-8363 (Linking)
VI  - 2
IP  - 1
DP  - 2013 Jan
TI  - Diabetic nephropathy and antioxidants.
PG  - 20-7
LID - 10.5812/nephropathol.9093 [doi]
AB  - CONTEXT: Oxidative stress has crucial role in pathogenesis of diabetic 
      nephropathy (DN). Despite satisfactory results from antioxidant therapy in 
      rodent, antioxidant therapy showed conflicting results in combat with DN in 
      diabetic patients. EVIDENCE ACQUISITIONS: Directory of Open Access Journals 
      (DOAJ), Google Scholar,Pubmed (NLM), LISTA (EBSCO) and Web of Science have been 
      searched. RESULTS: Treatment of DN in human are insufficient with rennin 
      angiotensin system (RAS) blockers, so additional agent ought to combine with this 
      management. Meanwhile based on DN pathogenesis and evidences in experimental and 
      human researches, the antioxidants are the best candidate. New multi-property 
      antioxidants may be improved human DN that show high power antioxidant capacity, 
      long half-life time, high permeability to mitochondrion, improve body 
      antioxidants enzymes activity and anti-inflammatory effects. CONCLUSIONS: Based 
      on this review and our studies on diabetic rats, rosmarinic acid a multi-property 
      antioxidant may be useful in DN patients, but of course, needs to be proven in 
      clinical trials studies.
FAU - Tavafi, Majid
AU  - Tavafi M
AD  - Department of Anatomy, Lorestan University of Medical Sciences, Faculty of 
      Medicine, Khoram Abad, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130101
PL  - Iran
TA  - J Nephropathol
JT  - Journal of nephropathology
JID - 101611182
PMC - PMC3886179
OTO - NOTNLM
OT  - Antioxidants
OT  - Diabetic nephropathy
OT  - Oxidative stress
EDAT- 2014/01/30 06:00
MHDA- 2014/01/30 06:01
PMCR- 2013/01/01
CRDT- 2014/01/30 06:00
PHST- 2012/10/07 00:00 [received]
PHST- 2012/10/15 00:00 [accepted]
PHST- 2014/01/30 06:00 [entrez]
PHST- 2014/01/30 06:00 [pubmed]
PHST- 2014/01/30 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.5812/nephropathol.9093 [doi]
PST - ppublish
SO  - J Nephropathol. 2013 Jan;2(1):20-7. doi: 10.5812/nephropathol.9093. Epub 2013 Jan 
      1.