PMID- 24475772
OWN - NLM
STAT- MEDLINE
DCOM- 20150828
LR  - 20220311
IS  - 1525-6065 (Electronic)
IS  - 1064-1955 (Linking)
VI  - 33
IP  - 3
DP  - 2014 Aug
TI  - Evaluation of the macula, retinal nerve fiber layer and choroid in preeclampsia, 
      healthy pregnant and healthy non-pregnant women using spectral-domain optical 
      coherence tomography.
PG  - 299-310
LID - 10.3109/10641955.2013.877924 [doi]
AB  - OBJECTIVE: To evaluate the macular, retinal nerve fiber layer (RNFL) and 
      choroidal thickness alterations by using spectral-domain optical coherence 
      tomography (SD-OCT) in preeclampsia and compare with healthy pregnant and healthy 
      non-pregnant controls. METHOD: The study population included healthy pregnant 
      control group (n: 25), healthy non-pregnant control group (n: 26) and study group 
      with preeclampsia (n: 27). Retinal thickness parameters were measured by SD-OCT. 
      RESULTS: There was a statistically significant difference among all of the groups 
      for choroidal thickness (p < 0.001). Choroidal thickness in preeclamptic women 
      was significantly thinner than healthy pregnant women. The most thick choroid 
      layer was detected in healthy pregnant group, and also the most thin choroidal 
      thickness was detected in healthy non-pregnant group (p < 0.001). Macular central 
      subfield and foveal center thickness were significantly thinner in preeclamptic 
      study and healthy pregnant groups than healthy non-pregnant group (p < 0.001). 
      However, there was no statistically significant difference between preeclamptic 
      study group and healthy pregnant group for both macular central subfield and 
      foveal center thickness. Average of RNFL thickness was significantly thicker in 
      healthy pregnant group than healthy non-pregnant group (p = 0.004). CONCLUSIONS: 
      This study revealed that choroidal thickness measured using SD-OCT increased in 
      women with preeclampsia and healthy pregnant women but the increase in choroidal 
      thickness in preeclampsia was lower than the healthy pregnant controls. This 
      lower rise in choroidal thickness can be generally attributed to the markedly 
      increased systemic vascular vasospasm secondary to preeclampsia.
FAU - Atas, Mustafa
AU  - Atas M
AD  - Department of Ophthalmology .
FAU - Acmaz, Gokhan
AU  - Acmaz G
FAU - Aksoy, Huseyin
AU  - Aksoy H
FAU - Demircan, Suleyman
AU  - Demircan S
FAU - Atas, Fatma
AU  - Atas F
FAU - Gulhan, Ahmet
AU  - Gulhan A
FAU - Zararsiz, Gokmen
AU  - Zararsiz G
LA  - eng
PT  - Journal Article
DEP - 20140129
PL  - England
TA  - Hypertens Pregnancy
JT  - Hypertension in pregnancy
JID - 9421297
SB  - IM
MH  - Adult
MH  - Choroid/*pathology
MH  - Female
MH  - Humans
MH  - Macula Lutea/*pathology
MH  - Nerve Fibers/*pathology
MH  - Pre-Eclampsia/*pathology
MH  - Pregnancy
MH  - Retinal Neurons/*pathology
MH  - Tomography, Optical Coherence
MH  - Young Adult
OTO - NOTNLM
OT  - Choroidal thickness
OT  - Macular thickness
OT  - Optical coherence tomography
OT  - Preeclampsia
OT  - Retinal nerve fiber layer
EDAT- 2014/01/31 06:00
MHDA- 2015/09/01 06:00
CRDT- 2014/01/31 06:00
PHST- 2014/01/31 06:00 [entrez]
PHST- 2014/01/31 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - 10.3109/10641955.2013.877924 [doi]
PST - ppublish
SO  - Hypertens Pregnancy. 2014 Aug;33(3):299-310. doi: 10.3109/10641955.2013.877924. 
      Epub 2014 Jan 29.