PMID- 24476223
OWN - NLM
STAT- MEDLINE
DCOM- 20150130
LR  - 20211021
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Print)
IS  - 1096-620X (Linking)
VI  - 17
IP  - 4
DP  - 2014 Apr
TI  - Oral administration of SSC201, a medicinal herbal formula, suppresses atopic 
      dermatitis-like skin lesions.
PG  - 496-504
LID - 10.1089/jmf.2013.2941 [doi]
AB  - Atopic dermatitis (AD) is a chronic inflammatory skin disease, which requires 
      safe and effective treatment. In this study, we evaluated the effects of SSC201, 
      a herbal formulation consisting of Stemonae Radix, Spirodelae Herba, and Cnidii 
      Fructus, on the development of AD induced by 2,4-dinitrochlorobenzene in the 
      NC/Nga murine model. Oral administration of SSC201 significantly reduced the 
      severity of dermatitis and the tendency of mice to scratch their lesions. SSC201 
      significantly reduced the thickening of the epidermis/dermis and the infiltration 
      of T cells, eosinophils, and mast cells into the dermis. These results were 
      supported by findings of reduced numbers of CD4(+), CCR3(+), and 
      CD117(+)FcvarepsilonRIalpha(+) cells in the skin. Furthermore, SSC201 significantly decreased 
      the number of CD4(+), CD8(+), and CD3(+)CD69(+) T cells in lymph nodes. SSC201 
      not only decreased the plasma levels of immunoglobulin E (IgE) and the numbers of 
      IgE-producing B cells (B220(+)CD23(+)), but also reduced the number of 
      eosinophils and the levels of eotaxin as well as concentrations of thymus and 
      activation-regulated chemokine in the periphery. Splenic levels of Th2 cytokines, 
      including interleukin (IL)-4, IL-5, and IL-13, were reduced, whereas the levels 
      of IL-12, a Th1 cytokine, were increased. Taken together, our data suggest that 
      SSC201 may be an effective therapeutic agent for the treatment of AD.
FAU - Park, Bo-Kyung
AU  - Park BK
AD  - 1 Laboratory of Pathology, College of Oriental Medicine, Daejeon University , 
      Daejeon, Korea.
FAU - Park, Yang-Chun
AU  - Park YC
FAU - Jung, In Chul
AU  - Jung IC
FAU - Kim, Seung-Hyung
AU  - Kim SH
FAU - Choi, Jung-Eun
AU  - Choi JE
FAU - Park, Sunyoung
AU  - Park S
FAU - Choi, Jeong June
AU  - Choi JJ
FAU - Jin, Mirim
AU  - Jin M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140129
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Interleukin-13)
RN  - 0 (Interleukin-5)
RN  - 0 (Plant Extracts)
RN  - 187348-17-0 (Interleukin-12)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Chemistry, Pharmaceutical
MH  - Dermatitis, Atopic/*drug therapy/immunology
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Interleukin-12/immunology
MH  - Interleukin-13/immunology
MH  - Interleukin-5/immunology
MH  - Male
MH  - Mast Cells/drug effects/immunology
MH  - Mice
MH  - Plant Extracts/*administration & dosage
MH  - Plants, Medicinal/*chemistry
MH  - T-Lymphocytes/drug effects/immunology
PMC - PMC3993068
EDAT- 2014/01/31 06:00
MHDA- 2015/01/31 06:00
PMCR- 2015/04/01
CRDT- 2014/01/31 06:00
PHST- 2014/01/31 06:00 [entrez]
PHST- 2014/01/31 06:00 [pubmed]
PHST- 2015/01/31 06:00 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - 10.1089/jmf.2013.2941 [pii]
AID - 10.1089/jmf.2013.2941 [doi]
PST - ppublish
SO  - J Med Food. 2014 Apr;17(4):496-504. doi: 10.1089/jmf.2013.2941. Epub 2014 Jan 29.