PMID- 24476425
OWN - NLM
STAT- MEDLINE
DCOM- 20141020
LR  - 20151119
IS  - 1551-3823 (Electronic)
IS  - 1551-3815 (Linking)
VI  - 33
IP  - 2
DP  - 2014 Apr
TI  - Inflammatory markers in umbilical cord blood from small-for-gestational-age 
      newborns.
PG  - 114-8
LID - 10.3109/15513815.2013.879239 [doi]
AB  - This study investigates the role of inflammation in intrauterine growth 
      retardation by exploring the levels of inflammatory markers in umbilical cord 
      blood from neonates who were born small-for-gestational-age (SGA) and comparing 
      them to neonates who were born appropriate-for-gestational-age (AGA). Interleukin 
      6 (IL-6), Tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP) were 
      measured by standard methods in term or near-term (gestational age >36 weeks) 
      neonates born SGA (n = 45) and a matched group of neonates born AGA (n = 45). 
      Infants exposed to maternal chronic diseases, diabetes or pre-eclampsia were 
      excluded. SGA was defined as two standard derivations below the expected for term 
      and gender. In multivariate regression analyses significant elevation in cord 
      blood concentration of IL-6 was demonstrated in the SGA group (mean 4.56 vs. 
      2.38, p = 0.002). The results indicate the presence of elevated inflammatory 
      markers in the cord blood from SGA infants compared to AGA infants, and 
      consequently the results suggest an inflammatory component in intrauterine growth 
      restriction (IUGR).
FAU - Lausten-Thomsen, Ulrik
AU  - Lausten-Thomsen U
AD  - 1 Department of Pediatric and Adolescent Medicine, University Hospital 
      Rigshospitalet , Copenhagen , Denmark.
FAU - Olsen, Marianne
AU  - Olsen M
FAU - Greisen, Gorm
AU  - Greisen G
FAU - Schmiegelow, Kjeld
AU  - Schmiegelow K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140129
PL  - England
TA  - Fetal Pediatr Pathol
JT  - Fetal and pediatric pathology
JID - 101230972
RN  - 0 (Biomarkers)
RN  - 0 (IL6 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
CIN - Fetal Pediatr Pathol. 2014 Jun;33(3):196-7. PMID: 24673641
MH  - Adult
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Case-Control Studies
MH  - Female
MH  - Fetal Blood/*metabolism
MH  - Fetal Growth Retardation/blood/etiology
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Small for Gestational Age/*blood
MH  - Inflammation/blood/complications
MH  - Inflammation Mediators/*blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Pregnancy
MH  - Reference Values
MH  - Tumor Necrosis Factor-alpha/blood
MH  - Young Adult
EDAT- 2014/01/31 06:00
MHDA- 2014/10/21 06:00
CRDT- 2014/01/31 06:00
PHST- 2014/01/31 06:00 [entrez]
PHST- 2014/01/31 06:00 [pubmed]
PHST- 2014/10/21 06:00 [medline]
AID - 10.3109/15513815.2013.879239 [doi]
PST - ppublish
SO  - Fetal Pediatr Pathol. 2014 Apr;33(2):114-8. doi: 10.3109/15513815.2013.879239. 
      Epub 2014 Jan 29.