PMID- 24477657
OWN - NLM
STAT- MEDLINE
DCOM- 20141124
LR  - 20211021
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 39
IP  - 4
DP  - 2014 Apr
TI  - MicroRNAs in neuroblastoma: small-sized players with a large impact.
PG  - 613-23
LID - 10.1007/s11064-014-1247-9 [doi]
AB  - Neuroblastoma, a malignant embryonal tumor of the sympathetic nervous system, is 
      the most common solid extracranial malignancy of childhood and accounts for 15 % 
      of all childhood cancer deaths. The biological behavior of neuroblastoma is 
      extensively heterogeneous, ranging from spontaneous regression to rapid 
      progression despite multimodal aggressive therapy. Although the molecular basis 
      of neuroblastoma has received considerable attention over the past decade, 
      elucidating the mechanisms for the aggressive progression of neuroblastoma is 
      needed for improving the efficacy of treatment. miRNAs (microRNAs) are small 
      non-coding RNA molecules generally 19-22 nucleotides in length. miRNAs regulate 
      60 % of human gene expression at the post-transcriptional level by targeting 
      regions of sequence complementarity on the 3'-untranslated regions (3'-UTRs) of 
      specific mRNAs. miRNAs can either cause degradation of mRNAs or can inhibit their 
      translation and therefore play major roles in normal growth and development. 
      miRNA dysregulation has oncogenic or tumor-suppressive functions in virtually all 
      forms of cancer, including neuroblastoma. The present review highlights the 
      current insights on dysregulated miRNAs in neuroblastoma and on their roles in 
      the diagnosis, prognosis, and treatment of this malignancy. As a rapidly evolving 
      field of basic and biomedical sciences, miRNA research holds a great potential to 
      impact on the management of neuroblastoma.
FAU - Zhi, Feng
AU  - Zhi F
AD  - Modern Medical Research Center, Third Affiliated Hospital of Soochow University, 
      185#, Juqian Road, Changzhou, 213003, Jiangsu, China.
FAU - Wang, Rong
AU  - Wang R
FAU - Wang, Qiang
AU  - Wang Q
FAU - Xue, Lian
AU  - Xue L
FAU - Deng, Danni
AU  - Deng D
FAU - Wang, Suinuan
AU  - Wang S
FAU - Yang, Yilin
AU  - Yang Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140130
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Biomarkers, Tumor/*genetics
MH  - Cell Differentiation/physiology
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - MicroRNAs/*genetics
MH  - Neuroblastoma/*diagnosis/*genetics
EDAT- 2014/01/31 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/01/31 06:00
PHST- 2013/11/13 00:00 [received]
PHST- 2014/01/21 00:00 [accepted]
PHST- 2013/12/22 00:00 [revised]
PHST- 2014/01/31 06:00 [entrez]
PHST- 2014/01/31 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1007/s11064-014-1247-9 [doi]
PST - ppublish
SO  - Neurochem Res. 2014 Apr;39(4):613-23. doi: 10.1007/s11064-014-1247-9. Epub 2014 
      Jan 30.