PMID- 24477969
OWN - NLM
STAT- MEDLINE
DCOM- 20140818
LR  - 20190115
IS  - 1552-8618 (Electronic)
IS  - 0730-7268 (Linking)
VI  - 33
IP  - 5
DP  - 2014 May
TI  - Fathead minnow (Pimephales promelas Rafinesque) exposure to three novel 
      brominated flame retardants in outdoor mesocosms: bioaccumulation and 
      biotransformation.
PG  - 1148-55
LID - 10.1002/etc.2541 [doi]
AB  - The phaseout of polybrominated diphenyl ethers (PBDEs) has prompted the search 
      for appropriate substitutes. These substitutes, referred to as novel brominated 
      flame retardants (NBFRs), are poorly characterized in terms of their persistence, 
      bioaccumulation, and toxicity. The authors assessed the bioaccumulation potential 
      of 3 non-PBDE brominated flame retardants: 1,2-bis(2,4,6-tribromophenoxy)ethane 
      (BTBPE), tetrabromobisphenol A bis(2,3-dibromopropylether) (TBBPA-BDBPE), and 
      BZ-54, a mixture of bis(2-ethylhexyl)tetrabromophthalate) (BEH-TEBP) and 
      2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB). Replicate outdoor aquatic 
      mesocosms were treated individually at concentrations designed to give a maximum 
      load of 500 ng/g of flame retardant in the upper 5 cm of the sediment. Caged 
      fathead minnows (Pimephales promelas, 24 fish per replicate) were introduced to 
      each mesocosm and acclimated for 10 d prior to exposure. The exposure period was 
      42 d, followed by 28 d of depuration after transfer to a control mesocosm, during 
      which physical, reproductive, and biochemical end points were examined. Tissue 
      samples were taken to measure the accumulation, depuration, and biotransformation 
      of NBFRs. Fathead minnows were observed to accumulate, after growth adjustment, 
      BTBPE (16-4203 ng/g lipid) and TBBPA-BDBPE (>1000 ng/g lipid) but with a lack of 
      consistent accumulation observed for EH-TBB and BEH-TEBP. However, limited 
      biologically meaningful or consistent responses were observed in the monitored 
      physical, reproductive, and biochemical parameters. Fathead minnows from each 
      treatment exhibited several brominated transformation products. The authors 
      conclude that these NBFRs have the potential to be bioaccumulative and persistent 
      in vivo and, therefore, warrant further study of physiological effects linked to 
      chronic, sublethal responses.
CI  - (c) 2014 SETAC.
FAU - de Jourdan, Benjamin P
AU  - de Jourdan BP
AD  - University of Guelph, Guelph, Ontario, Canada.
FAU - Hanson, Mark L
AU  - Hanson ML
FAU - Muir, Derek C G
AU  - Muir DC
FAU - Solomon, Keith R
AU  - Solomon KR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140321
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (2-ethylhexyl 2,3,4,5-tetrabromobenzoate)
RN  - 0 (Benzoates)
RN  - 0 (Bromobenzenes)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Flame Retardants)
RN  - 0 (Phthalic Acids)
RN  - 0 (Polybrominated Biphenyls)
RN  - 34I00D6RNM (1,2-bis(2,4,6-tribromophenoxy)ethane)
RN  - 413M0N3V1G (bis(2-ethylhexyl) 2,3,4,5-tetrabromophthalate)
RN  - FQI02RFC3A (tetrabromobisphenol A)
SB  - IM
MH  - Animals
MH  - Benzoates/chemistry/metabolism
MH  - Biotransformation
MH  - Bromobenzenes/chemistry/metabolism
MH  - Cyprinidae/growth & development/*metabolism
MH  - Environmental Exposure
MH  - Environmental Pollutants/chemistry/*metabolism
MH  - Flame Retardants/*metabolism
MH  - Phthalic Acids/chemistry/metabolism
MH  - Polybrominated Biphenyls/chemistry/metabolism
OTO - NOTNLM
OT  - BTBPE
OT  - BZ-54
OT  - Bioaccumulation
OT  - Biotransformation
OT  - Flame retardant
OT  - TBBAPA-BDBPE
EDAT- 2014/01/31 06:00
MHDA- 2014/08/19 06:00
CRDT- 2014/01/31 06:00
PHST- 2013/08/20 00:00 [received]
PHST- 2013/10/10 00:00 [revised]
PHST- 2014/01/26 00:00 [accepted]
PHST- 2014/01/31 06:00 [entrez]
PHST- 2014/01/31 06:00 [pubmed]
PHST- 2014/08/19 06:00 [medline]
AID - 10.1002/etc.2541 [doi]
PST - ppublish
SO  - Environ Toxicol Chem. 2014 May;33(5):1148-55. doi: 10.1002/etc.2541. Epub 2014 
      Mar 21.