PMID- 24479831
OWN - NLM
STAT- MEDLINE
DCOM- 20141121
LR  - 20140826
IS  - 1600-0463 (Electronic)
IS  - 0903-4641 (Linking)
VI  - 122
IP  - 9
DP  - 2014 Sep
TI  - Serum concentrations of cytokines in infants with retinopathy of prematurity.
PG  - 818-23
LID - 10.1111/apm.12223 [doi]
AB  - Retinopathy of prematurity (ROP) is the leading cause of blindness in preterm 
      infants. In this study, we investigated the cytokine levels in cord blood of 
      normal preterm neonates and preterm infants developed ROP. Serum levels of 10 
      cytokines in umbilical cord blood were measured by multiplex protein arrays from 
      62 healthy preterm neonates and 30 preterm neonate cases who developed ROP at 
      later stage. Results showed that serum levels of cytokines including interleukin 
      7 (IL-7), monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein 
      1 alpha (MIP-1alpha), and macrophage inflammatory protein 1 beta (MIP-1beta) were 
      significantly increased in cases who developed ROP than in healthy preterm 
      neonates (3.5-fold, 3.2-fold, 3.4-fold, and 2.1-fold, respectively), whereas 
      levels of these four cytokines did not reveal any significant differences between 
      healthy preterm infants and normal infants. When comparing the expression of 
      cytokines in ROP patients with different clinical parameters, ROP cases whose 
      gestational age at delivery earlier than 29.0 weeks demonstrated increased levels 
      of MCP-1 and MIP-1beta than those later than 29.0 weeks (p < 0.05). Also, ROP cases 
      with birth weight less than 1.28 kg revealed significantly higher level of MIP-1beta 
      than those who were heavier than 1.28 kg (p < 0.05). These data indicated that 
      levels of IL-7, MCP-1, MIP-1alpha, and MIP-1beta were associated with increased risk of 
      ROP, in which MIP-1beta may be further correlated with the severity of ROP.
CI  - (c) 2014 APMIS. Published by John Wiley & Sons Ltd.
FAU - Yu, Honghua
AU  - Yu H
AD  - Department of Ophthalmology, General Hospital of Guangzhou Military Command of 
      PLA, Guangzhou, China; State Key Laboratory of Ophthalmology, Zhongshan 
      Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
FAU - Yuan, Ling
AU  - Yuan L
FAU - Zou, Yuping
AU  - Zou Y
FAU - Peng, Lianghong
AU  - Peng L
FAU - Wang, Yong
AU  - Wang Y
FAU - Li, Tao
AU  - Li T
FAU - Tang, Shibo
AU  - Tang S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140131
PL  - Denmark
TA  - APMIS
JT  - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JID - 8803400
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCL4 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Cytokines)
RN  - 0 (IL7 protein, human)
RN  - 0 (Interleukin-7)
SB  - IM
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood
MH  - Chemokine CCL3/blood
MH  - Chemokine CCL4/blood
MH  - Cytokines/*blood
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Gestational Age
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infant, Premature/*blood
MH  - Interleukin-7/blood
MH  - Male
MH  - Premature Birth/*blood
MH  - Retinopathy of Prematurity/*blood
OTO - NOTNLM
OT  - Cytokine
OT  - retinopathy of prematurity
EDAT- 2014/02/01 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/02/01 06:00
PHST- 2013/09/02 00:00 [received]
PHST- 2013/11/04 00:00 [accepted]
PHST- 2014/02/01 06:00 [entrez]
PHST- 2014/02/01 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1111/apm.12223 [doi]
PST - ppublish
SO  - APMIS. 2014 Sep;122(9):818-23. doi: 10.1111/apm.12223. Epub 2014 Jan 31.