PMID- 2448012
OWN - NLM
STAT- MEDLINE
DCOM- 19880310
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 435
IP  - 1-2
DP  - 1987 Dec 1
TI  - Central interactions between dihydropyridines and cholinergic systems in the 
      control of blood pressure in rat.
PG  - 160-6
AB  - Intracerebroventricular (i.c.v.) injection of the 1,4-dihydropyridine (DHP) 
      calcium channel agonist, Bay K8644 (30 micrograms/kg) increased mean blood 
      pressure and the K+-evoked release of [3H]acetylcholine ([3H]ACh) from 
      hippocampal slices in spontaneously hypertensive rats (SHR). The Bay 
      K8644-induced hypertension was inhibited by a pretreatment with methylatropine 
      (80 micrograms/kg i.c.v.). In SHR, nicardipine, a DHP calcium channel antagonist, 
      reduced mean blood pressure when i.c.v. injected (10 micrograms/kg). The 
      nicardipine-induced hypotension was reduced by a pretreatment with 
      hemicholinium-3 (20 micrograms, i.c.v.). Nicardipine (1 microM) did not modify, 
      in SHR, the K+-evoked release of [3H]ACh, but inhibited the Bay K8644-induced 
      increase in the ACh release. In normotensive rats, neither Bay K8644 nor 
      nicardipine modify blood pressure, when centrally injected, or the stimulated 
      release of [3H]ACh from hippocampal slices. The participation of central DHP 
      sites in the cholinergic transmission in genetic hypertension is discussed.
FAU - Brisac, A M
AU  - Brisac AM
AD  - Departement de Pharmacologie et Unite INSERM 228, Faculte de Medecine 
      Broussais-Hotel Dieu, Paris, France.
FAU - Huguet, F
AU  - Huguet F
FAU - Champeroux, P
AU  - Champeroux P
FAU - Montastruc, J L
AU  - Montastruc JL
FAU - Lucet, B
AU  - Lucet B
FAU - Gerard, P
AU  - Gerard P
FAU - Laurent, S
AU  - Laurent S
FAU - Narcisse, G
AU  - Narcisse G
FAU - Schmitt, H
AU  - Schmitt H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Atropine Derivatives)
RN  - 0 (Dihydropyridines)
RN  - 0 (Hexamethonium Compounds)
RN  - 312-45-8 (Hemicholinium 3)
RN  - 3C9PSP36Z2 (Hexamethonium)
RN  - 71145-03-4 (3-Pyridinecarboxylic acid, 
      1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester)
RN  - 7M8K3P6I89 (1,4-dihydropyridine)
RN  - 80719I460H (methylatropine)
RN  - CZ5312222S (Nicardipine)
RN  - N9YNS0M02X (Acetylcholine)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - 3-Pyridinecarboxylic acid, 
      1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl 
      ester/*pharmacology
MH  - Acetylcholine/*metabolism
MH  - Animals
MH  - Atropine Derivatives/pharmacology
MH  - Blood Pressure/*drug effects
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Dihydropyridines/*pharmacology
MH  - Hemicholinium 3/pharmacology
MH  - Hexamethonium
MH  - Hexamethonium Compounds/pharmacology
MH  - Hippocampus/drug effects/*physiology
MH  - In Vitro Techniques
MH  - Male
MH  - Nicardipine/*pharmacology
MH  - Potassium/pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred Strains
MH  - Reference Values
MH  - Species Specificity
EDAT- 1987/12/01 00:00
MHDA- 2000/06/01 09:00
CRDT- 1987/12/01 00:00
PHST- 1987/12/01 00:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 1987/12/01 00:00 [entrez]
AID - 0006-8993(87)91597-6 [pii]
AID - 10.1016/0006-8993(87)91597-6 [doi]
PST - ppublish
SO  - Brain Res. 1987 Dec 1;435(1-2):160-6. doi: 10.1016/0006-8993(87)91597-6.