PMID- 24480636
OWN - NLM
STAT- MEDLINE
DCOM- 20141028
LR  - 20221207
IS  - 1879-114X (Electronic)
IS  - 0149-2918 (Linking)
VI  - 36
IP  - 2
DP  - 2014 Feb 1
TI  - Clinical and economic outcomes in medication-adherent and -nonadherent patients 
      with type 2 diabetes mellitus in the Republic of Korea.
PG  - 245-54
LID - S0149-2918(13)01156-9 [pii]
LID - 10.1016/j.clinthera.2013.12.012 [doi]
AB  - BACKGROUND: The prevalence and social burden of type 2 diabetes mellitus (T2DM) 
      is increasing. Medication adherence is necessary for positive outcomes in 
      patients with T2DM. OBJECTIVE: This study evaluated the association between 
      medication adherence and clinical/economic outcomes in patients with T2DM in the 
      Republic of Korea over a 3-year period. METHODS: This study used data from the 
      Korean National Diabetes Program at 5 hospitals. Medication possession ratios of 
      >/=90% and <90% were used to define adherent and nonadherent groups, respectively. 
      The degree of glycemic control, changes in blood pressure and lipid profiles, and 
      health care costs were compared. RESULTS: Of the 608 patients, 472 were 
      medication adherent and 136 were nonadherent. The adherent patients displayed 
      improved fasting blood glucose and hemoglobin A1c during the study. Diastolic 
      blood pressure and total cholesterol were lower at 36 months, and lower 
      low-density lipoprotein cholesterol was noted at baseline and 24 months. The 
      total health care costs were $1861, $2060, and $1924, respectively, versus $1617, 
      $1751, and $1602 during the 3-year study period for the adherent group versus the 
      nonadherent group, respectively (P = 0.316, 0.627, and 0.172, respectively), 
      whereas the outpatient drug costs were $1143, $1176, and $1162 in the adherent 
      group versus $925, $778, and $914 in the nonadherent group (P = 0.002, P < 0.001, 
      and P = 0.001). CONCLUSIONS: The adherent patients displayed better glycemic 
      control and lipid profiles. Medication-related expenses were higher in the 
      adherent group, but overall health care costs, including hospitalization costs, 
      were similar between the 2 groups.
CI  - Copyright (c) 2014 Elsevier HS Journals, Inc. All rights reserved.
FAU - An, So-Yeon
AU  - An SY
AD  - Department of Endocrinology and Metabolism, Ajou University School of Medicine, 
      Suwon, Republic of Korea.
FAU - Kim, Hae Jin
AU  - Kim HJ
AD  - Department of Endocrinology and Metabolism, Ajou University School of Medicine, 
      Suwon, Republic of Korea.
FAU - Chun, Ki Hong
AU  - Chun KH
AD  - Department of Preventive Medicine and Public Health, Ajou University School of 
      Medicine, Suwon, Republic of Korea.
FAU - Kim, Tae Ho
AU  - Kim TH
AD  - Department of Internal Medicine, Kwandong University College of Medicine, 
      Gangneung, Republic of Korea.
FAU - Jeon, Ja Young
AU  - Jeon JY
AD  - Department of Endocrinology and Metabolism, Ajou University School of Medicine, 
      Suwon, Republic of Korea.
FAU - Kim, Dae Jung
AU  - Kim DJ
AD  - Department of Endocrinology and Metabolism, Ajou University School of Medicine, 
      Suwon, Republic of Korea.
FAU - Han, Seung Jin
AU  - Han SJ
AD  - Department of Endocrinology and Metabolism, Ajou University School of Medicine, 
      Suwon, Republic of Korea.
FAU - Kim, Young Seol
AU  - Kim YS
AD  - Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Woo, Jeong Taek
AU  - Woo JT
AD  - Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Ahn, Kyu Jeung
AU  - Ahn KJ
AD  - Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Park, Yongsoo
AU  - Park Y
AD  - Department of Internal Medicine, Hanyang University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Nam, Moonsuk
AU  - Nam M
AD  - Department of Internal Medicine, Inha University College of Medicine, Incheon, 
      Republic of Korea.
FAU - Baik, Sei Hyun
AU  - Baik SH
AD  - Department of Internal Medicine, Korea University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Lee, Kwan-Woo
AU  - Lee KW
AD  - Department of Endocrinology and Metabolism, Ajou University School of Medicine, 
      Suwon, Republic of Korea. Electronic address: lkw65@ajou.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140127
PL  - United States
TA  - Clin Ther
JT  - Clinical therapeutics
JID - 7706726
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Aged
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 2/*drug therapy/epidemiology/*physiopathology
MH  - Drug Costs/*statistics & numerical data
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - *Health Care Costs/statistics & numerical data
MH  - Hospital Costs/statistics & numerical data
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Male
MH  - *Medication Adherence/psychology
MH  - Middle Aged
MH  - Prospective Studies
MH  - Republic of Korea
OTO - NOTNLM
OT  - adherence to medication
OT  - clinical and economic outcomes
OT  - type 2 diabetes mellitus
EDAT- 2014/02/01 06:00
MHDA- 2014/10/29 06:00
CRDT- 2014/02/01 06:00
PHST- 2013/11/06 00:00 [received]
PHST- 2013/12/03 00:00 [revised]
PHST- 2013/12/20 00:00 [accepted]
PHST- 2014/02/01 06:00 [entrez]
PHST- 2014/02/01 06:00 [pubmed]
PHST- 2014/10/29 06:00 [medline]
AID - S0149-2918(13)01156-9 [pii]
AID - 10.1016/j.clinthera.2013.12.012 [doi]
PST - ppublish
SO  - Clin Ther. 2014 Feb 1;36(2):245-54. doi: 10.1016/j.clinthera.2013.12.012. Epub 
      2014 Jan 27.