PMID- 2448067
OWN - NLM
STAT- MEDLINE
DCOM- 19880302
LR  - 20211203
IS  - 0009-9147 (Print)
IS  - 0009-9147 (Linking)
VI  - 34
IP  - 1
DP  - 1988 Jan
TI  - Monitoring hepatocellular carcinoma by using a monoclonal immunoenzymometric 
      assay for alpha-fetoprotein.
PG  - 76-81
AB  - A monoclonal immunoenzymometric assay for alpha-fetoprotein (M-AFP) was evaluated 
      with respect to its utility in monitoring hepatocellular carcinoma (HCC) 
      patients. Earlier (Clin Chem 1986;32:1318-22), we found this immunoassay to 
      demonstrate abilities similar to polyclonal AFP assays, and we suggested that 
      changes in M-AFP correlated with changes in intrahepatic tumor volume in most HCC 
      patients. In the present study, 107 HCC patients were evaluated between 1978 and 
      1986. Patient demographics characterized this study population as being similar 
      to those seen in regions with low incidence of HCC. Changes in serum M-AFP 
      concentration correlated moderately (r = 0.55) with changes in intrahepatic tumor 
      volume. The AFP concentration in serum was found to be a statistically 
      significant independent predictor of survival; patients with above-normal M-AFP 
      (AFP[+]) at presentation demonstrated a median survival time of 10 months, 
      compared with 16 months for patients with "normal" values for M-AFP (AFP[-]) (P = 
      0.008). This prognostic pattern persisted when adjusted for serum bilirubin 
      concentration (AFP[+] 12 months vs AFP[-] 29 months, P = 0.01).
FAU - Kelsten, M L
AU  - Kelsten ML
AD  - Department of Laboratory Medicine, Johns Hopkins Medical Institutions, Baltimore, 
      MD 21205.
FAU - Chan, D W
AU  - Chan DW
FAU - Bruzek, D J
AU  - Bruzek DJ
FAU - Rock, R C
AU  - Rock RC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Chem
JT  - Clinical chemistry
JID - 9421549
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Surface Antigens)
RN  - 0 (alpha-Fetoproteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antibodies, Monoclonal
MH  - Carcinoma, Hepatocellular/*analysis/complications/pathology
MH  - Child
MH  - Female
MH  - Hepatitis B/complications/metabolism
MH  - Hepatitis B Antibodies/analysis
MH  - Hepatitis B Surface Antigens/analysis
MH  - Humans
MH  - *Immunoenzyme Techniques
MH  - Liver Cirrhosis/complications/metabolism
MH  - Liver Diseases/metabolism
MH  - Liver Neoplasms/*analysis/complications/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Racial Groups
MH  - alpha-Fetoproteins/*analysis
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
PST - ppublish
SO  - Clin Chem. 1988 Jan;34(1):76-81.