PMID- 24481260
OWN - NLM
STAT- MEDLINE
DCOM- 20140506
LR  - 20140307
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 55
IP  - 3
DP  - 2014 Mar 6
TI  - Assessing residual visual function in severe vision loss.
PG  - 1332-8
LID - 10.1167/iovs.13-12657 [doi]
AB  - PURPOSE: Vision restoration is a fast-approaching reality for some people with 
      profound vision loss. In order to reliably determine treatment efficacy, accurate 
      assessment of baseline residual visual function is critical. The purpose of this 
      study was to compare residual function as detected on Goldman visual field (GVF) 
      and full-field ERG (ffERG), and correlate with the remaining photoreceptor layer 
      as determined by spectral-domain optical coherence tomography (SD-OCT), in 
      subjects with severe vision loss. METHODS: Fifty-four subjects with advanced 
      retinitis pigmentosa and no discernible signal on ffERG were included. Trace 
      residual function was assessed using discrete Fourier transform (DFT) analysis of 
      the 30-Hz flicker ffERG and the percentage of remaining GVF. The horizontal 
      extent of the outer nuclear layer (ONL) on SD-OCT was assessed. RESULTS: Thirty 
      percent of the study eyes had a 30-Hz flicker response after DFT analysis of the 
      ffERG, and 57% had a measurable GVF. Thirty-five percent had a visible ONL on 
      SD-OCT. There was no significant correlation between the magnitude of the 30-Hz 
      flicker response and the percentage of remaining GVF (r = 0.172, P = 0.213) or 
      the extent of remaining central photoreceptors (r = 0.258, P = 0.06). Only 17% of 
      the eyes had all three parameters detected. CONCLUSIONS: Discrete Fourier 
      transform analysis of the 30Hz-flicker ffERG response and GVF can detect trace 
      residual function. Evidence of this residual function is not always supported by 
      the structural correlate of a measurable ONL. Our findings highlight the 
      importance of completing a multimodal assessment to accurately define the 
      important parameters of retinal structure and function in people with profound 
      vision loss.
FAU - Ayton, Lauren N
AU  - Ayton LN
AD  - Centre for Eye Research Australia, The University of Melbourne, Royal Victorian 
      Eye and Ear Hospital, East Melbourne, Victoria, Australia.
FAU - Apollo, Nicholas V
AU  - Apollo NV
FAU - Varsamidis, Mary
AU  - Varsamidis M
FAU - Dimitrov, Peter N
AU  - Dimitrov PN
FAU - Guymer, Robyn H
AU  - Guymer RH
FAU - Luu, Chi D
AU  - Luu CD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140306
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Electroretinography
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retina/pathology/*physiopathology
MH  - Retinitis Pigmentosa/complications/diagnosis/physiopathology
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/methods
MH  - Vision, Low/*diagnosis/etiology/physiopathology
MH  - Visual Acuity/*physiology
MH  - Visual Field Tests
MH  - Visual Fields/*physiology
OTO - NOTNLM
OT  - electroretinography
OT  - low vision
OT  - retinitis pigmentosa
OT  - vision regeneration
OT  - visual function
EDAT- 2014/02/01 06:00
MHDA- 2014/05/07 06:00
CRDT- 2014/02/01 06:00
PHST- 2014/02/01 06:00 [entrez]
PHST- 2014/02/01 06:00 [pubmed]
PHST- 2014/05/07 06:00 [medline]
AID - iovs.13-12657 [pii]
AID - 10.1167/iovs.13-12657 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2014 Mar 6;55(3):1332-8. doi: 10.1167/iovs.13-12657.