PMID- 24481644
OWN - NLM
STAT- MEDLINE
DCOM- 20141007
LR  - 20240229
IS  - 1098-1136 (Electronic)
IS  - 0894-1491 (Linking)
VI  - 62
IP  - 4
DP  - 2014 Apr
TI  - Oligodendrogenesis and myelinogenesis during postnatal development effect of 
      glatiramer acetate.
PG  - 649-65
LID - 10.1002/glia.22632 [doi]
AB  - Myelinogenesis in the mammal nervous system occurs predominantly postnatally. 
      Glatiramer acetate (GA), a drug for the treatment for multiple sclerosis (MS), 
      has been shown to induce immunomodulation and neuroprotection in the inflamed CNS 
      in MS and in experimental autoimmune encephalomyelitis (EAE). Here we 
      investigated whether GA can affect myelinogenesis and oligodendrogenesis in the 
      developing nervous system under nonpathological conditions. Towards this end we 
      studied myelination in mice injected daily by GA, at postnatal Days 7-21. 
      Immunohistological and ultrastructural analyses revealed significant elevation in 
      the number of myelinated axons as well as in the thickness of the myelin 
      encircling them and their resulting g-ratios, in spinal cords of GA-injected mice 
      compared with their PBS-injected littermates, at postnatal Day 14. Elevation in 
      myelinated axons was detected also in the peripheral ventral roots of the motor 
      nerves. GA induced also an increase in axonal diameter, implying an effect on the 
      overall development of the nervous system. A prominent elevation in the amount of 
      progenitor oligodendrocytes and their BrdU incorporation, as well as in mature 
      oligodendrocytes indicated that the effect of GA is linked to increased 
      proliferation and differentiation along the oligodendroglial maturation cascade. 
      In addition, elevation in insulin-like growth factor (IGF-1) and brain-derived 
      neurotrophic factor (BDNF) was found in the white matter of the GA-injected mice. 
      Furthermore, a functional advantage in rotating rod test was exhibited by 
      GA-injected mice over their littermates at postnatal Day 21. These cumulative 
      findings corroborate the beneficial effect of GA on oligodendrogenesis and 
      myelination.
CI  - Copyright (c) 2014 Wiley Periodicals, Inc.
FAU - From, Renana
AU  - From R
AD  - Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel, 
      76100.
FAU - Eilam, Raya
AU  - Eilam R
FAU - Bar-Lev, Dekel D
AU  - Bar-Lev DD
FAU - Levin-Zaidman, Smadar
AU  - Levin-Zaidman S
FAU - Tsoory, Michael
AU  - Tsoory M
FAU - LoPresti, Patrizia
AU  - LoPresti P
FAU - Sela, Michael
AU  - Sela M
FAU - Arnon, Ruth
AU  - Arnon R
FAU - Aharoni, Rina
AU  - Aharoni R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140130
PL  - United States
TA  - Glia
JT  - Glia
JID - 8806785
RN  - 0 (Antigens)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (chondroitin sulfate proteoglycan 4)
RN  - 5M691HL4BO (Glatiramer Acetate)
RN  - 0 (Immunosuppressive Agents)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Olig2 protein, mouse)
RN  - 0 (Oligodendrocyte Transcription Factor 2)
RN  - 0 (Peptides)
RN  - 0 (Proteoglycans)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Animals, Newborn
MH  - Antigens/metabolism
MH  - Basic Helix-Loop-Helix Transcription Factors/metabolism
MH  - *Brain/drug effects/growth & development/ultrastructure
MH  - Cell Proliferation/drug effects
MH  - Exploratory Behavior/drug effects
MH  - *Gene Expression Regulation, Developmental/drug effects
MH  - Glatiramer Acetate
MH  - *Immunosuppressive Agents/pharmacology
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Mice, Inbred C57BL
MH  - Microscopy, Electron, Transmission
MH  - Motor Activity/drug effects
MH  - *Myelin Sheath/drug effects/physiology/ultrastructure
MH  - Nerve Tissue Proteins/metabolism
MH  - Oligodendrocyte Transcription Factor 2
MH  - *Oligodendroglia/drug effects/physiology/ultrastructure
MH  - Organogenesis/drug effects
MH  - *Peptides/pharmacology
MH  - Proteoglycans/metabolism
MH  - Time Factors
MH  - Multiple Sclerosis
OTO - NOTNLM
OT  - myelination
OT  - oligodendrocyte proliferation and differentiation
OT  - postnatal development
EDAT- 2014/02/01 06:00
MHDA- 2014/10/07 06:00
CRDT- 2014/02/01 06:00
PHST- 2013/11/18 00:00 [received]
PHST- 2013/12/29 00:00 [revised]
PHST- 2014/01/06 00:00 [accepted]
PHST- 2014/02/01 06:00 [entrez]
PHST- 2014/02/01 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - 10.1002/glia.22632 [doi]
PST - ppublish
SO  - Glia. 2014 Apr;62(4):649-65. doi: 10.1002/glia.22632. Epub 2014 Jan 30.