PMID- 24481879
OWN - NLM
STAT- MEDLINE
DCOM- 20150105
LR  - 20211021
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 41
IP  - 5
DP  - 2014 May
TI  - Association of ESR1 and C6orf97 gene polymorphism with osteoporosis in 
      postmenopausal women.
PG  - 3235-43
LID - 10.1007/s11033-014-3186-6 [doi]
AB  - The estrogen receptor 1 (ESR1) and Chromosome 6 Open Reading Frame 97 (C6orf97) 
      gene polymorphisms were earlier reported to be associated with osteoporosis in 
      the European cohort. The aim of this study was to investigate the association of 
      four single nucleotide polymorphisms (SNP) with bone mineral density (BMD), 
      fracture, vertebral fracture, bone turnover or 25-hydroxyvitamin D [25(OH)D] in 
      1,753 randomly selected postmenopausal women in China. Vertebral fracture, BMD of 
      lumbar spine (2-4), femoral neck and total hip were measured respectively. Serum 
      N-terminal procollagen of type 1 collagen (P1NP), beta-isomerized type I collagen 
      C-telopeptide breakdown products (beta-CTX) and 25(OH)D3 were also determined. 
      Binary logistic regression revealed significant associations between fracture 
      risk with rs1999805 (P=0.041, OR 1.633, 95%CI 1.020-2.616) and rs6929137 
      (P=0.005, OR 1.932, 95%CI 1.226-3.045) in recessive model. Significant 
      association was also observed between vertebral fracture risk and rs1038304 
      (P=0.039, OR 0.549, 95%CI 0.311-0.969) in recessive model. Liner regression 
      analyses showed that only the CC group of rs4870044 was significantly associated 
      with total hip in dominant model (P=0.034). Our findings suggest that ESR1 and 
      C6orf97 gene polymorphism is associated with fracture and vertebral fracture risk 
      in Chinese postmenopausal women.
FAU - Luo, Lianmei
AU  - Luo L
AD  - Department of Obstetrics and Gynecology & Beijing Tsinghua Chang Gung Hospital of 
      Tsinghua University, Beijing, 102218, China.
FAU - Xia, Weibo
AU  - Xia W
FAU - Nie, Min
AU  - Nie M
FAU - Sun, Yue
AU  - Sun Y
FAU - Jiang, Yan
AU  - Jiang Y
FAU - Zhao, Jing
AU  - Zhao J
FAU - He, Shuli
AU  - He S
FAU - Xu, Ling
AU  - Xu L
LA  - eng
PT  - Journal Article
DEP - 20140131
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Chromosomes, Human, Pair 6
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Middle Aged
MH  - Osteoporosis, Postmenopausal/complications/*genetics
MH  - Osteoporotic Fractures/genetics
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Quantitative Trait Loci
EDAT- 2014/02/01 06:00
MHDA- 2015/01/06 06:00
CRDT- 2014/02/01 06:00
PHST- 2013/12/19 00:00 [received]
PHST- 2014/01/18 00:00 [accepted]
PHST- 2014/02/01 06:00 [entrez]
PHST- 2014/02/01 06:00 [pubmed]
PHST- 2015/01/06 06:00 [medline]
AID - 10.1007/s11033-014-3186-6 [doi]
PST - ppublish
SO  - Mol Biol Rep. 2014 May;41(5):3235-43. doi: 10.1007/s11033-014-3186-6. Epub 2014 
      Jan 31.