PMID- 24482044
OWN - NLM
STAT- MEDLINE
DCOM- 20141021
LR  - 20231213
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 9
IP  - 4
DP  - 2014 Apr
TI  - MicroRNA‑34a/c function as tumor suppressors in Hep‑2 laryngeal carcinoma cells 
      and may reduce GALNT7 expression.
PG  - 1293-8
LID - 10.3892/mmr.2014.1929 [doi]
AB  - A family of small non-coding RNAs, ~22 nt in length, known as microRNAs (miRNAs), 
      regulating ~30% of all human gene expression, have been reported to be involved 
      in the pathogenesis of a number of types of cancers, including laryngeal squamous 
      cell carcinoma (LSCC). In the current study, miR-34a and miR-34c were observed to 
      be downregulated in human LSCC tissues. Ectopic expression of miR-34a and miR-34c 
      in Hep-2 cells significantly induced the cell proliferation and migration ability 
      in vitro. 
      UDP-N-acetyl-alpha-D-galactosamine:polypeptide-N-acetylgalactosaminyltransferase 7 
      (GALNT7), whose expression is negatively regulated by miR-34a and miR-34c in 
      Hep-2 cells, is con fi rmed to be a novel direct target gene of miR-34a and miR-34c. 
      In conclusion, the current results suggest that miR-34a and miR-34c may function 
      as tumor suppressors in LSCC through downregulation of GALNT7. The study of 
      miR-34a, miR-34c and its novel target, GALNT7, may serve as novel potential 
      makers for LSCC therapy.
FAU - Li, Wei
AU  - Li W
AD  - Department of Otolaryngology, Head and Neck Surgery, The First People's Hospital 
      of Jining, Shandong 272000, P.R. China.
FAU - Ma, Huiping
AU  - Ma H
AD  - Department of Respiration, The First People's Hospital of Jining, Shandong 
      272000, P.R. China.
FAU - Sun, Ji
AU  - Sun J
AD  - Department of Otolaryngology, Head and Neck Surgery, Harbin Medical University 
      Cancer Institute and Hospital, Heilongjiang 150081, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20140130
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (MIRN34 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Messenger)
RN  - EC 2.4.1.- (N-Acetylgalactosaminyltransferases)
SB  - IM
MH  - Carcinoma, Squamous Cell/enzymology/genetics/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation
MH  - Down-Regulation/genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - *Genes, Tumor Suppressor
MH  - Humans
MH  - Laryngeal Neoplasms/*enzymology/*genetics/pathology
MH  - MicroRNAs/genetics/*metabolism
MH  - N-Acetylgalactosaminyltransferases/*genetics/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Reproducibility of Results
MH  - Polypeptide N-acetylgalactosaminyltransferase
EDAT- 2014/02/01 06:00
MHDA- 2014/10/22 06:00
CRDT- 2014/02/01 06:00
PHST- 2013/04/27 00:00 [received]
PHST- 2014/01/10 00:00 [accepted]
PHST- 2014/02/01 06:00 [entrez]
PHST- 2014/02/01 06:00 [pubmed]
PHST- 2014/10/22 06:00 [medline]
AID - 10.3892/mmr.2014.1929 [doi]
PST - ppublish
SO  - Mol Med Rep. 2014 Apr;9(4):1293-8. doi: 10.3892/mmr.2014.1929. Epub 2014 Jan 30.