PMID- 24482714
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140131
LR  - 20211021
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 7
IP  - 1
DP  - 2014
TI  - Therapeutic effect of transplanting bone mesenchymal stem cells on the hind 
      limbs' motor function of rats with acute spinal cord injury.
PG  - 262-7
AB  - PURPOSE: To research the therapeutic effect of the allograft of bone mesenchymal 
      stem cells (BMSCs) on hind limbs' motor function of rats that underwent acute 
      injury to their spinal nerve. DESIGN: 40 Wistar rat samples with the acute injury 
      to the spinal cord were established and divided into the transplantation group 
      and the control group, 20 for each group; One week after injury, BMSCs were 
      slowly injected into the center of the injured spinal cord of the rats, and the 
      physiological saline was injected into the control group. MAIN OUTCOME MEASURES: 
      The rehabilitation of the motor function of the rats' hind limbs was observed; 
      furthermore, eight weeks after the injury, the protein disparity of the nerve 
      growth factor (NGF) and brain-derived neurotrophic factor (BDNF) between the two 
      groups of rats was noted. RESULTS: The rehabilitation of the hind limbs' motor 
      function of the transplantation group was significantly better than that of the 
      control group from the third week on after injury, and the difference was of 
      significance (P<0.05). CONCLUSIONS: Transplanting BMSCs can boost the protein 
      expression of NGF and BDNF in the rats which undergo acute injury to their spinal 
      nerves. It can, therefore, significantly improve the rehabilitation of the motor 
      function of their hind limbs. The improvement is associated with the 
      transplantation of BMSCs which are beneficial for regeneration and repair of the 
      rat's spinal nerves.
FAU - Song, Qinghua
AU  - Song Q
AD  - The Center of Physical Health, Henan Polytechnic University Jiaozuo 454000, Henan 
      Province, P. R. China.
FAU - Xu, Rongmei
AU  - Xu R
AD  - The Center of Physical Health, Henan Polytechnic University Jiaozuo 454000, Henan 
      Province, P. R. China.
FAU - Zhang, Quanhai
AU  - Zhang Q
AD  - The Lab of Human Body Science, Henan Polytechnic University Jiaozuo 454000, Henan 
      Province, P. R. China.
FAU - Ma, Ming
AU  - Ma M
AD  - The Center of Physical Health, Henan Polytechnic University Jiaozuo 454000, Henan 
      Province, P. R. China.
FAU - Zhao, Xinping
AU  - Zhao X
AD  - The Lab of Human Body Science, Henan Polytechnic University Jiaozuo 454000, Henan 
      Province, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20140115
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC3902266
OTO - NOTNLM
OT  - Mesenchymal stem cells
OT  - repair
OT  - spinal nerves
OT  - transplantation
EDAT- 2014/02/01 06:00
MHDA- 2014/02/01 06:01
PMCR- 2014/01/15
CRDT- 2014/02/01 06:00
PHST- 2013/11/06 00:00 [received]
PHST- 2013/12/28 00:00 [accepted]
PHST- 2014/02/01 06:00 [entrez]
PHST- 2014/02/01 06:00 [pubmed]
PHST- 2014/02/01 06:01 [medline]
PHST- 2014/01/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2014 Jan 15;7(1):262-7. eCollection 2014.