PMID- 24482744
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20210203
LR  - 20211021
IS  - 2162-4011 (Print)
IS  - 2162-402X (Electronic)
IS  - 2162-4011 (Linking)
VI  - 2
IP  - 11
DP  - 2013 Nov 1
TI  - Antitumor immune responses mediated by dendritic cells: How signals derived from 
      dying cancer cells drive antigen cross-presentation.
PG  - e26403
LID - e26403
AB  - Dendritic cells (DCs) are essential for the induction of adaptive immune 
      responses against malignant cells by virtue of their capacity to effectively 
      cross-present exogenous antigens to T lymphocytes. Dying cancer cells are indeed 
      a rich source of antigens that may be harnessed for the development of DC-based 
      vaccines. In particular, malignant cells succumbing to apoptosis, rather than 
      necrosis, appear to release antigens in a manner that allows for the elicitation 
      of adaptive immune responses. In this review, we describe the processes that 
      mediate the cross-presentation of antigens released by apoptotic cancer cells to 
      CD8(+) T lymphocytes, resulting in the activation of protective tumor-specific 
      immune responses.
FAU - Spel, Lotte
AU  - Spel L
AD  - U-DANCE and Laboratory of Translational Immunology; University Medical Center 
      Utrecht; Utrecht, The Netherlands.
FAU - Boelens, Jaap-Jan
AU  - Boelens JJ
AD  - U-DANCE and Laboratory of Translational Immunology; University Medical Center 
      Utrecht; Utrecht, The Netherlands.
FAU - Nierkens, Stefan
AU  - Nierkens S
AD  - U-DANCE and Laboratory of Translational Immunology; University Medical Center 
      Utrecht; Utrecht, The Netherlands.
FAU - Boes, Marianne
AU  - Boes M
AD  - U-DANCE and Laboratory of Translational Immunology; University Medical Center 
      Utrecht; Utrecht, The Netherlands.
LA  - eng
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20131021
PL  - United States
TA  - Oncoimmunology
JT  - Oncoimmunology
JID - 101570526
PMC - PMC3894247
OTO - NOTNLM
OT  - DAMPs
OT  - apoptotic
OT  - cross-presentation
OT  - dendritic cells
OT  - necrotic
OT  - storage compartments
OT  - type 1 interferon
EDAT- 2014/02/01 06:00
MHDA- 2014/02/01 06:01
PMCR- 2013/10/21
CRDT- 2014/02/01 06:00
PHST- 2013/08/05 00:00 [received]
PHST- 2013/09/06 00:00 [revised]
PHST- 2013/09/06 00:00 [accepted]
PHST- 2014/02/01 06:00 [entrez]
PHST- 2014/02/01 06:00 [pubmed]
PHST- 2014/02/01 06:01 [medline]
PHST- 2013/10/21 00:00 [pmc-release]
AID - 2013ONCOIMM0222R [pii]
AID - 10.4161/onci.26403 [doi]
PST - ppublish
SO  - Oncoimmunology. 2013 Nov 1;2(11):e26403. doi: 10.4161/onci.26403. Epub 2013 Oct 
      21.