PMID- 24483149
OWN - NLM
STAT- MEDLINE
DCOM- 20141201
LR  - 20211021
IS  - 1750-2659 (Electronic)
IS  - 1750-2640 (Print)
IS  - 1750-2640 (Linking)
VI  - 8
IP  - 3
DP  - 2014 May
TI  - Epidemiology of respiratory viral infections in children enrolled in a study of 
      influenza vaccine effectiveness.
PG  - 293-301
LID - 10.1111/irv.12229 [doi]
AB  - BACKGROUND: Influenza-like illness (ILI) confers a high annual morbidity in young 
      children. We report the epidemiology of ILIs in children who participated in an 
      influenza vaccine effectiveness study during the 2010 Southern Hemisphere 
      influenza season in Sydney, Australia. METHODS: Children aged 0.5-3 years were 
      prospectively recruited from child care centres (CCCs). We classified them as 
      fully vaccinated, partially vaccinated and unvaccinated according to their 
      receipt of unadjuvanted vaccines containing influenza A (H1N1)pdm09. For 13 weeks 
      commencing 30 July 2010, parents reported when their children developed an ILI 
      (fever >/=37.8 degrees C/feverishness plus >/=1 respiratory symptom) and collected nose 
      and/or throat swabs for multiplex respiratory virus polymerase chain reaction 
      (PCR) testing. Health impacts were assessed by telephone interview at enrolment 
      and two weeks after each ILI. RESULTS: There were 124 ILIs reported in 105 of 381 
      enrolled children. Swabs were taken in 117 ILIs: 175 viruses were identified from 
      103 swabs. Adeno- and rhinoviruses were most frequently identified; 44% of swabs 
      yielded multiple viruses. No virus was associated with more severe symptoms, 
      although rhinovirus-related ILIs lasted longer. Nose swabs had a higher virus 
      detection rate than throat swabs. Influenza-vaccinated children were 1.6 times (P 
      = 0.001) more likely than unvaccinated children to have a non-influenza ILI. 
      CONCLUSION: Adeno- and rhinoviruses were the most common viruses causing ILI. 
      Swabs taken by parents are an effective method for sample collection. 
      Influenza-like illness was more common in children vaccinated against influenza 
      in this observational study, but prior health-seeking behaviour may have 
      contributed to this difference.
CI  - (c) 2014 The Authors. Influenza and Other Respiratory Viruses Published by John 
      Wiley & Sons Ltd.
FAU - Dierig, Alexa
AU  - Dierig A
AD  - National Centre for Immunisation Research and Surveillance, The Children's 
      Hospital at Westmead, Westmead, NSW, Australia; University Children's Hospital 
      both Basel, Basel, Switzerland.
FAU - Heron, Leon G
AU  - Heron LG
FAU - Lambert, Stephen B
AU  - Lambert SB
FAU - Yin, Jiehui Kevin
AU  - Yin JK
FAU - Leask, Julie
AU  - Leask J
FAU - Chow, Maria Yui Kwan
AU  - Chow MY
FAU - Sloots, Theo P
AU  - Sloots TP
FAU - Nissen, Michael D
AU  - Nissen MD
FAU - Ridda, Iman
AU  - Ridda I
FAU - Booy, Robert
AU  - Booy R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140131
PL  - England
TA  - Influenza Other Respir Viruses
JT  - Influenza and other respiratory viruses
JID - 101304007
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Australia/epidemiology
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - Influenza A Virus, H1N1 Subtype/immunology
MH  - Influenza Vaccines/*administration & dosage/immunology
MH  - Influenza, Human/epidemiology/immunology/*prevention & control/virology
MH  - Male
MH  - Respiratory Tract Infections/epidemiology/immunology/*prevention & 
      control/virology
MH  - Seasons
MH  - Vaccination
PMC - PMC4181477
OTO - NOTNLM
OT  - Children
OT  - influenza
OT  - respiratory viral infections
EDAT- 2014/02/04 06:00
MHDA- 2014/12/15 06:00
PMCR- 2014/05/01
CRDT- 2014/02/04 06:00
PHST- 2013/11/24 00:00 [accepted]
PHST- 2014/02/04 06:00 [entrez]
PHST- 2014/02/04 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
PHST- 2014/05/01 00:00 [pmc-release]
AID - 10.1111/irv.12229 [doi]
PST - ppublish
SO  - Influenza Other Respir Viruses. 2014 May;8(3):293-301. doi: 10.1111/irv.12229. 
      Epub 2014 Jan 31.