PMID- 2448392
OWN - NLM
STAT- MEDLINE
DCOM- 19880315
LR  - 20190723
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 90
IP  - 2
DP  - 1988 Feb
TI  - Prevalence and functional role of anti-IgE autoantibodies in urticarial 
      syndromes.
PG  - 213-7
AB  - The prevalence of autoantibodies of immunoglobulin G (IgG) and immunoglobulin M 
      (IgM) classes directed against myeloma immunoglobulin E (IgE) were determined in 
      distinct subsets of urticaria, using an enzyme immunoassay. IgG anti-IgE 
      antibodies were found in five of nine patients (55%) with cold urticaria, four of 
      eight patients (50%) with urticarial vasculitis, and three of six patients (50%) 
      with chronic urticaria. IgM anti-IgE antibodies were found exclusively in cold 
      urticaria (two of nine patients, 22%). Heating of these sera increased the 
      binding to IgE, suggesting immune complex formation. Several positive sera were 
      capable of inducing histamine release from normal peripheral basophils and caused 
      a wheal-flare response upon intradermal injection. Sera containing such 
      autoantibodies from three cold urticaria patients were studied for passive 
      transfer of cold sensitivity. One serum containing IgG anti-IgE gave a strongly 
      positive transfer test at 5 h but not 48 h, suggesting a pathogenic role for the 
      IgG.
FAU - Gruber, B L
AU  - Gruber BL
AD  - Department of Medicine, SUNY at Stony Brook 11794-8161.
FAU - Baeza, M L
AU  - Baeza ML
FAU - Marchese, M J
AU  - Marchese MJ
FAU - Agnello, V
AU  - Agnello V
FAU - Kaplan, A P
AU  - Kaplan AP
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antibodies, Anti-Idiotypic/*analysis
MH  - Autoantibodies/*analysis/physiology
MH  - Basophils/metabolism
MH  - Cold Temperature
MH  - Histamine Release
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunoglobulin E/*immunology
MH  - Immunoglobulin G/analysis
MH  - Immunoglobulin M/analysis
MH  - Urticaria/*immunology
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
AID - S0022-202X(88)91145-1 [pii]
AID - 10.1111/1523-1747.ep12462239 [doi]
PST - ppublish
SO  - J Invest Dermatol. 1988 Feb;90(2):213-7. doi: 10.1111/1523-1747.ep12462239.