PMID- 24484170
OWN - NLM
STAT- MEDLINE
DCOM- 20140616
LR  - 20140421
IS  - 1945-7170 (Electronic)
IS  - 0013-7227 (Linking)
VI  - 155
IP  - 5
DP  - 2014 May
TI  - The medio-basal hypothalamus as a dynamic and plastic reproduction-related 
      kisspeptin-gnrh-pituitary center in fish.
PG  - 1874-86
LID - 10.1210/en.2013-1894 [doi]
AB  - Kisspeptin regulates reproductive events, including puberty and ovulation, 
      primarily via GnRH neurons. Prolonged treatment of prepubertal striped bass 
      females with kisspeptin (Kiss) 1 or Kiss2 peptides failed to enhance puberty but 
      suggested a gnrh-independent pituitary control pathway. Kiss2 inhibited, but 
      Kiss1 stimulated, FShbeta expression and gonadal development, although 
      hypophysiotropic gnrh1 and gnrh receptor expression remained unchanged. In situ 
      hybridization and immunohistochemistry on brains and pituitaries revealed a 
      differential plasticity between the 2 kisspeptin neurons. The differences were 
      most pronounced at the prespawning phase in 2 regions along the path of gnrh1 
      axons: the nucleus lateralis tuberis (NLT) and the neurohypophysis. Kiss1 neurons 
      appeared in the NLT and innervated the neurohypophysis of prespawning males and 
      females, reaching Lh gonadotropes in the proximal pars distalis. Males, at all 
      reproductive stages, had Kiss2 innervations in the NLT and the neurohypophysis, 
      forming large axonal bundles in the former and intermingling with gnrh1 axons. 
      Unlike in males, only preovulatory females had massive NLT-neurohypophysis 
      staining of kiss2. Kiss2 neurons showed a distinct appearance in the NLT pars 
      ventralis-equivalent region only in spawning zebrafish, indicating that this 
      phenomenon is widespread. These results underscore the NLT as important nuclei 
      for kisspeptin action in 2 facets: 1) kisspeptin-gnrh interaction, both 
      kisspeptins are involved in the regulation of gnrh release, in a stage- and 
      sex-dependent manner, especially at the prespawning phase; and 2) 
      gnrh-independent effect of Kiss peptides on the pituitary, which together with 
      the plastic nature of their neuronal projections to the pituitary implies that a 
      direct gonadotropic regulation is plausible.
FAU - Zmora, Nilli
AU  - Zmora N
AD  - Department of Marine Biotechnology (N.Z., J.S., Y.Z.), University of Maryland 
      Baltimore County and Institute of Marine and Environmental Technology, Baltimore, 
      Maryland 21202; Faculty of Agriculture, Food and Environment (M.G., B.L.-S.), The 
      Hebrew University, Rehobot, Israel 76100; and Ifremer (A.S.), Unite de 
      Physiologie Fonctionnelle des Organismes Marins, Laboratoire des sciences de 
      l'environnement marin Unite mixte de recherche 6539, Plouzane 29280, France.
FAU - Stubblefield, John
AU  - Stubblefield J
FAU - Golan, Matan
AU  - Golan M
FAU - Servili, Arianna
AU  - Servili A
FAU - Levavi-Sivan, Berta
AU  - Levavi-Sivan B
FAU - Zohar, Yonathan
AU  - Zohar Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140131
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Drug Implants)
RN  - 0 (Fertility Agents, Female)
RN  - 0 (Fish Proteins)
RN  - 0 (Follicle Stimulating Hormone, beta Subunit)
RN  - 0 (KISS1 peptide, Xenopus)
RN  - 0 (Kisspeptins)
RN  - 0 (Xenopus Proteins)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Aquaculture
MH  - Axons/drug effects/metabolism
MH  - Bass/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Drug Implants
MH  - Female
MH  - Fertility Agents, Female/pharmacology
MH  - Fish Proteins/biosynthesis/genetics/*metabolism
MH  - Follicle Stimulating Hormone, beta Subunit/biosynthesis/genetics/metabolism
MH  - Gonadotropin-Releasing Hormone/genetics/*metabolism
MH  - Hypothalamo-Hypophyseal System/cytology/drug effects/growth & 
      development/*metabolism
MH  - Hypothalamus, Middle/cytology/drug effects/growth & development/metabolism
MH  - Kisspeptins/administration & dosage/*metabolism/pharmacology
MH  - Maryland
MH  - Pituitary Gland, Posterior/cytology/drug effects/growth & development/metabolism
MH  - *Sexual Maturation/drug effects
MH  - Up-Regulation/drug effects
MH  - Xenopus Proteins/administration & dosage/*metabolism/pharmacology
EDAT- 2014/02/04 06:00
MHDA- 2014/06/17 06:00
CRDT- 2014/02/04 06:00
PHST- 2014/02/04 06:00 [entrez]
PHST- 2014/02/04 06:00 [pubmed]
PHST- 2014/06/17 06:00 [medline]
AID - 10.1210/en.2013-1894 [doi]
PST - ppublish
SO  - Endocrinology. 2014 May;155(5):1874-86. doi: 10.1210/en.2013-1894. Epub 2014 Jan 
      31.