PMID- 24484701
OWN - NLM
STAT- MEDLINE
DCOM- 20140731
LR  - 20220410
IS  - 1878-0814 (Electronic)
IS  - 1877-1173 (Linking)
VI  - 122
DP  - 2014
TI  - BDNF-TrkB receptor regulation of distributed adult neural plasticity, memory 
      formation, and psychiatric disorders.
PG  - 169-92
LID - B978-0-12-420170-5.00006-4 [pii]
LID - 10.1016/B978-0-12-420170-5.00006-4 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) and its single transmembrane receptor, 
      tropomysin-related kinase B (TrkB), are essential for adult synaptic plasticity 
      and the formation of memories. However, there are regional and task-dependent 
      differences underlying differential mechanisms of BDNF-TrkB function in the 
      formation of these memories. Additionally, the BDNF pathway has been implicated 
      in several psychiatric disorders including posttraumatic stress disorder, phobia, 
      and panic disorder. Gaining a better understanding of this pathway and the 
      neurobiology of memory through fundamental research may be helpful to identify 
      effective prevention and treatment approaches both for diseases of memory deficit 
      as well as in cases of enhanced aversive memory, such as in anxiety disorders.
CI  - (c) 2014 Elsevier Inc. All rights reserved.
FAU - Andero, Raul
AU  - Andero R
AD  - Department of Psychiatry and Behavioral Sciences, Emory University School of 
      Medicine, Atlanta, Georgia, USA; Yerkes National Primate Research Center, 
      Atlanta, Georgia, USA.
FAU - Choi, Dennis C
AU  - Choi DC
AD  - Department of Psychiatry and Behavioral Sciences, Emory University School of 
      Medicine, Atlanta, Georgia, USA; Yerkes National Primate Research Center, 
      Atlanta, Georgia, USA.
FAU - Ressler, Kerry J
AU  - Ressler KJ
AD  - Department of Psychiatry and Behavioral Sciences, Emory University School of 
      Medicine, Atlanta, Georgia, USA; Yerkes National Primate Research Center, 
      Atlanta, Georgia, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland, 
      USA.
LA  - eng
GR  - MH071537/MH/NIMH NIH HHS/United States
GR  - MH096764/MH/NIMH NIH HHS/United States
GR  - P51RR000165/RR/NCRR NIH HHS/United States
GR  - Howard Hughes Medical Institute/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Prog Mol Biol Transl Sci
JT  - Progress in molecular biology and translational science
JID - 101498165
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Memory/*physiology
MH  - Mental Disorders/genetics/*metabolism/*pathology
MH  - Neuronal Plasticity/*physiology
MH  - Receptor, trkB/genetics/*metabolism
MH  - Signal Transduction
OTO - NOTNLM
OT  - Amygdala
OT  - BDNF
OT  - Fear
OT  - Hippocampus
OT  - LTP
OT  - Memory
OT  - PTSD
OT  - Prefrontal cortex
OT  - Synaptic plasticity
OT  - TrkB
EDAT- 2014/02/04 06:00
MHDA- 2014/08/01 06:00
CRDT- 2014/02/04 06:00
PHST- 2014/02/04 06:00 [entrez]
PHST- 2014/02/04 06:00 [pubmed]
PHST- 2014/08/01 06:00 [medline]
AID - B978-0-12-420170-5.00006-4 [pii]
AID - 10.1016/B978-0-12-420170-5.00006-4 [doi]
PST - ppublish
SO  - Prog Mol Biol Transl Sci. 2014;122:169-92. doi: 
      10.1016/B978-0-12-420170-5.00006-4.