PMID- 24485038
OWN - NLM
STAT- MEDLINE
DCOM- 20140718
LR  - 20181202
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1331
DP  - 2014 Feb 28
TI  - An automated solid-phase microextraction method based on magnetic molecularly 
      imprinted polymer as fiber coating for detection of trace estrogens in milk 
      powder.
PG  - 10-8
LID - S0021-9673(14)00058-2 [pii]
LID - 10.1016/j.chroma.2014.01.016 [doi]
AB  - A new automated solid-phase micro extraction (SPME) sampling method was developed 
      for quantitative enrichment of estrogens (ES) from milk powder, using magnetic 
      molecularly imprinted polymer (MMIP) as fiber coating. The method (MMIP-SPME) was 
      built with several electromagnetic stainless steel fibers, placed in parallel for 
      simultaneously extraction. The MMIP was synthesized using core-shell Fe3O4@SiO2 
      nanoparticles (NPs) as magnetic support. Estradiol (E2) was employed as the 
      template molecule, acrylamide (AA) as functional monomer, and ethylene glycol 
      dimethacrylate (EGDMA) as cross-linker. MMIP can be easily absorbed or desorbed 
      from fibers when the current is turned on or off, creating magnetism. Compared to 
      traditional MIP-SPME, the prepared procedure of MMIP-SPME is time-saving and 
      organic solvent-free. The proposed device significantly improved the efficiency 
      of separation and enrichment of estrogens from complex matrices thereby and 
      facilitating the pretreatment steps by electromagnetically controlled extraction 
      fibers to achieve full automation. Several experimental parameters were studied, 
      including extraction and desorption kinetics, solution pH, desorption solution, 
      ratio, and shuttle rate. The newly developed MMIP-SPME showed good sensitivity 
      and high binding capacity, fast adsorption kinetics and desorption kinetics for 
      estrone (E1), estradiol (E2), estriol (E3) and diethylstilbestrol (DES) under 
      optimized conditions. The detection limits for the four estrogens were 
      1.5-5.5ngg(-1) with excellent reproducibility (RSD values less than 7.1%) when 
      milk powder samples spiked with analytes at 20, 100 and 250ngg(-1) were studied.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Lan, Hangzhen
AU  - Lan H
AD  - Faculty of Marine Science, Ningbo University,Ningbo 315211, China.
FAU - Gan, Ning
AU  - Gan N
AD  - Faculty of Material Science and Chemical Engineering, Ningbo University, Ningbo 
      315211,China. Electronic address: ganning@nbu.edu.cn.
FAU - Pan, Daodong
AU  - Pan D
AD  - Faculty of Marine Science, Ningbo University,Ningbo 315211, China. Electronic 
      address: daodongpan@163.com.
FAU - Hu, Futao
AU  - Hu F
AD  - Faculty of Marine Science, Ningbo University,Ningbo 315211, China.
FAU - Li, Tianhua
AU  - Li T
AD  - Faculty of Material Science and Chemical Engineering, Ningbo University, Ningbo 
      315211,China.
FAU - Long, Nengbing
AU  - Long N
AD  - Faculty of Material Science and Chemical Engineering, Ningbo University, Ningbo 
      315211,China.
FAU - Qiao, Li
AU  - Qiao L
AD  - Faculty of Marine Science, Ningbo University,Ningbo 315211, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140115
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Acrylic Resins)
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Estrogens)
RN  - 0 (Methacrylates)
RN  - 0 (Powders)
RN  - 2DI9HA706A (Estrone)
RN  - 4TI98Z838E (Estradiol)
RN  - 731DCA35BT (Diethylstilbestrol)
RN  - 7BK5G69305 (ethylene dimethacrylate)
RN  - 9003-05-8 (polyacrylamide)
RN  - FB33469R8E (Estriol)
SB  - IM
MH  - Acrylic Resins/*chemistry
MH  - Adsorption
MH  - Animals
MH  - Cross-Linking Reagents/chemistry
MH  - Diethylstilbestrol/analysis
MH  - Estradiol/analysis
MH  - Estriol/analysis
MH  - Estrogens/*analysis
MH  - Estrone/analysis
MH  - Methacrylates/chemistry
MH  - Milk/*chemistry
MH  - Molecular Imprinting
MH  - Powders
MH  - Reproducibility of Results
MH  - Solid Phase Microextraction/instrumentation/*methods
OTO - NOTNLM
OT  - Automation
OT  - Estrogens
OT  - High performance liquid chromatography
OT  - Magnetic molecularly imprinted polymer
OT  - Solid-phase microextraction
EDAT- 2014/02/04 06:00
MHDA- 2014/07/19 06:00
CRDT- 2014/02/04 06:00
PHST- 2013/10/01 00:00 [received]
PHST- 2014/01/05 00:00 [revised]
PHST- 2014/01/10 00:00 [accepted]
PHST- 2014/02/04 06:00 [entrez]
PHST- 2014/02/04 06:00 [pubmed]
PHST- 2014/07/19 06:00 [medline]
AID - S0021-9673(14)00058-2 [pii]
AID - 10.1016/j.chroma.2014.01.016 [doi]
PST - ppublish
SO  - J Chromatogr A. 2014 Feb 28;1331:10-8. doi: 10.1016/j.chroma.2014.01.016. Epub 
      2014 Jan 15.