PMID- 24485586 OWN - NLM STAT- MEDLINE DCOM- 20150422 LR - 20160526 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 153 IP - 1-3 DP - 2014 Mar TI - White matter pathway organization of the reward system is related to positive and negative symptoms in schizophrenia. PG - 136-42 LID - S0920-9964(14)00018-8 [pii] LID - 10.1016/j.schres.2014.01.015 [doi] AB - The reward system in schizophrenia has been linked to the emergence of delusions on the one hand and to negative symptoms such as affective flattening on the other hand. Previous Diffusion Tensor Imaging (DTI) studies reported white matter microstructure alterations of regions related to the reward system. The present study aimed at extending these findings by specifically investigating connection pathways of the reward system in schizophrenia. Therefore, 24 patients with schizophrenia and 22 healthy controls matched for age and gender underwent DTI-scans. Using a probabilistic fiber tracking approach we bilaterally extracted pathways connecting the ventral tegmental area (VTA) with the nucleus accumbens (NAcc), the medial and lateral orbitofrontal cortices (mOFC, lOFC), the dorsolateral prefrontal cortex (dlPFC) and the amygdala; as well as pathways connecting NAcc with mOFC, lOFC, dlPFC and amygdala resulting in a total of 18 connections. Probability indices forming part of a bundle of interest (PIBI) were compared between groups using independent t-tests. In 6 connection pathways PIBI-values were increased in schizophrenia. In 3 of these pathways the spatial extension of connection pathways was decreased. In schizophrenia patients, there was a negative correlation of PIBI-values and PANSS negative scores in the left VTA-amygdala and in the left NAcc-mOFC connection. A sum score of delusions and hallucinations correlated positively with PIBI-values of the left amygdala-NAcc connection. Structural organization of specific segments of white matter pathways of the reward system in schizophrenia may contribute to the emergence of delusions and negative symptoms in schizophrenia. CI - Copyright (c) 2014 Elsevier B.V. All rights reserved. FAU - Bracht, Tobias AU - Bracht T AD - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: bracht@puk.unibe.ch. FAU - Horn, Helge AU - Horn H AD - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: horn@puk.unibe.ch. FAU - Strik, Werner AU - Strik W AD - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: strik@puk.unibe.ch. FAU - Federspiel, Andrea AU - Federspiel A AD - University Hospital of Psychiatry, Department of Psychiatric Neurophysiology, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: Federspiel@puk.unibe.ch. FAU - Razavi, Nadja AU - Razavi N AD - University Hospital of Psychiatry, Department of Psychiatric Neurophysiology, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: razavi@puk.unibe.ch. FAU - Stegmayer, Katharina AU - Stegmayer K AD - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: stegmayer@puk.unibe.ch. FAU - Wiest, Roland AU - Wiest R AD - Institute of Diagnostic and Interventional Neuroradiology, Inselspital, University of Bern, Freiburgstrasse, 3010 Bern, Switzerland. Electronic address: roland.wiest@insel.ch. FAU - Dierks, Thomas AU - Dierks T AD - University Hospital of Psychiatry, Department of Psychiatric Neurophysiology, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: Dierks@puk.unibe.ch. FAU - Muller, Thomas J AU - Muller TJ AD - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: Mueller@puk.unibe.ch. FAU - Walther, Sebastian AU - Walther S AD - University Hospital of Psychiatry, University of Bern, Bolligenstrasse 111, 3000 Bern 60, Switzerland. Electronic address: walther@puk.unibe.ch. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20140130 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Adult MH - Anisotropy MH - Brain/*pathology MH - Case-Control Studies MH - Diffusion Tensor Imaging MH - Female MH - Humans MH - Image Processing, Computer-Assisted MH - Male MH - Middle Aged MH - Nerve Fibers, Myelinated/*pathology MH - Neural Pathways/*pathology MH - Psychiatric Status Rating Scales MH - Schizophrenia/*pathology/*physiopathology MH - Statistics as Topic MH - Young Adult OTO - NOTNLM OT - Delusions OT - Diffusion Tensor Imaging OT - Fiber tracking OT - Hallucinations OT - Salience system EDAT- 2014/02/04 06:00 MHDA- 2015/04/23 06:00 CRDT- 2014/02/04 06:00 PHST- 2013/07/03 00:00 [received] PHST- 2013/12/10 00:00 [revised] PHST- 2014/01/10 00:00 [accepted] PHST- 2014/02/04 06:00 [entrez] PHST- 2014/02/04 06:00 [pubmed] PHST- 2015/04/23 06:00 [medline] AID - S0920-9964(14)00018-8 [pii] AID - 10.1016/j.schres.2014.01.015 [doi] PST - ppublish SO - Schizophr Res. 2014 Mar;153(1-3):136-42. doi: 10.1016/j.schres.2014.01.015. Epub 2014 Jan 30.