PMID- 24485916
OWN - NLM
STAT- MEDLINE
DCOM- 20141113
LR  - 20161125
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 265
DP  - 2014 May 15
TI  - Diverse effect of different odor stimuli on behavior and Fos protein production 
      in the olfactory system neurogenic region of adult rats.
PG  - 38-48
LID - S0166-4328(14)00037-0 [pii]
LID - 10.1016/j.bbr.2014.01.023 [doi]
AB  - Previously it has been demonstrated that processes of postnatal neurogenesis in 
      the olfactory system neurogenic region-the subventricular zone (SVZ), rostral 
      migratory stream (RMS), and olfactory bulb (OB) can be significantly altered by 
      different factors of an environment. However, the mechanisms involved in 
      regulation of neurogenesis by exogenous factors in the olfactory system remain 
      unclear. The purpose of the present study was to contribute to the understanding 
      of these mechanisms by immunohistochemical assessment of Fos protein induction in 
      areas of adult neurogenesis. To evaluate the coordinate activation of Fos 
      production in neurons of the olfactory system neurogenic region, a brief exposure 
      to artificial odor (eau de Cologne) or naturalistic odor (cat odor) has been used 
      in alert rats. Our results revealed that the effects of these odors are easily 
      distinguishable at both the behavioral and the morphological level. Cat odor 
      induced greater changes in anxiety level, and produced typical pattern of Fos 
      activation in the accessory olfactory bulb (AOB), a brain region associated with 
      defensive behavior. An important finding is, that next to distinct Fos expression 
      in the OB and the AOB, Fos positive cells have been found also within the SVZ/RMS 
      of the odor stimulated rats. Interestingly, Fos expression in the RMS was 
      detected only after exposure to artificial odor stimulus. These results provide 
      new evidence that some SVZ/RMS cells have complete prerequisites necessary for 
      the Fos signal transduction cascade.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Fabianova, Kamila
AU  - Fabianova K
AD  - Institute of Neurobiology, Slovak Academy of Sciences, Soltesovej 4, 04001, 
      Kosice, Slovak Republic. Electronic address: lievajova@saske.sk.
FAU - Martoncikova, Marcela
AU  - Martoncikova M
AD  - Institute of Neurobiology, Slovak Academy of Sciences, Soltesovej 4, 04001, 
      Kosice, Slovak Republic.
FAU - Fabian, Dusan
AU  - Fabian D
AD  - Institute of Animal Physiology, Slovak Academy of Science, Soltesovej 4, 04001, 
      Kosice, Slovak Republic.
FAU - Blasko, Juraj
AU  - Blasko J
AD  - Institute of Neurobiology, Slovak Academy of Sciences, Soltesovej 4, 04001, 
      Kosice, Slovak Republic.
FAU - Racekova, Eniko
AU  - Racekova E
AD  - Institute of Neurobiology, Slovak Academy of Sciences, Soltesovej 4, 04001, 
      Kosice, Slovak Republic.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140129
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 53-59-8 (NADP)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Cats
MH  - Exploratory Behavior/*physiology
MH  - Lateral Ventricles/cytology/metabolism
MH  - Locomotion/*physiology
MH  - Male
MH  - NADP/metabolism
MH  - Neurogenesis/*physiology
MH  - *Odorants
MH  - Olfactory Pathways/*cytology/*metabolism
MH  - Proto-Oncogene Proteins c-fos/*metabolism
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Adult neurogenesis
OT  - Fos protein
OT  - anxiety
OT  - artificial odor
OT  - cat odor
EDAT- 2014/02/04 06:00
MHDA- 2014/11/14 06:00
CRDT- 2014/02/04 06:00
PHST- 2013/12/02 00:00 [received]
PHST- 2014/01/14 00:00 [revised]
PHST- 2014/01/20 00:00 [accepted]
PHST- 2014/02/04 06:00 [entrez]
PHST- 2014/02/04 06:00 [pubmed]
PHST- 2014/11/14 06:00 [medline]
AID - S0166-4328(14)00037-0 [pii]
AID - 10.1016/j.bbr.2014.01.023 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 May 15;265:38-48. doi: 10.1016/j.bbr.2014.01.023. Epub 2014 
      Jan 29.