PMID- 24486158
OWN - NLM
STAT- MEDLINE
DCOM- 20140527
LR  - 20231213
IS  - 1879-3185 (Electronic)
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 317
DP  - 2014 Mar 20
TI  - Developmental cigarette smoke exposure: hippocampus proteome and metabolome 
      profiles in low birth weight pups.
PG  - 40-9
LID - S0300-483X(14)00007-9 [pii]
LID - 10.1016/j.tox.2014.01.006 [doi]
AB  - Exposure to cigarette smoke during development is linked to neurodevelopmental 
      delays and cognitive impairment including impulsivity, attention deficit 
      disorder, and lower IQ. However, brain region specific biomolecular alterations 
      induced by developmental cigarette smoke exposure (CSE) remain largely 
      unexplored. In the current molecular phenotyping study, a mouse model of 'active' 
      developmental CSE (serum cotinine > 50 ng/mL) spanning pre-implantation through 
      third trimester-equivalent brain development (gestational day (GD) 1 through 
      postnatal day (PD) 21) was utilized. Hippocampus tissue collected at the time of 
      cessation of exposure was processed for gel-based proteomic and non-targeted 
      metabolomic profiling with partial least squares-discriminant analysis (PLS-DA) 
      for selection of features of interest. Ingenuity pathway analysis was utilized to 
      identify candidate molecular and metabolic pathways impacted within the 
      hippocampus. CSE impacted glycolysis, oxidative phosphorylation, fatty acid 
      metabolism, and neurodevelopment pathways within the developing hippocampus.
CI  - Copyright (c) 2014 Elsevier Ireland Ltd. All rights reserved.
FAU - Neal, Rachel E
AU  - Neal RE
AD  - Department of Environmental and Occupational Health Sciences, School of Public 
      Health and Information Sciences, University of Louisville, Louisville, KY, USA; 
      Birth Defects Center, University of Louisville, Louisville, KY, USA. Electronic 
      address: rachel.neal@louisville.edu.
FAU - Chen, Jing
AU  - Chen J
AD  - Department of Environmental and Occupational Health Sciences, School of Public 
      Health and Information Sciences, University of Louisville, Louisville, KY, USA.
FAU - Jagadapillai, Rekha
AU  - Jagadapillai R
AD  - Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of 
      Louisville, Louisville, KY, USA.
FAU - Jang, Hyejeong
AU  - Jang H
AD  - Department of Biostatistics and Bioinformatics, School of Public Health and 
      Information Sciences, University of Louisville, Louisville, KY, USA.
FAU - Abomoelak, Bassam
AU  - Abomoelak B
AD  - Department of Environmental and Occupational Health Sciences, School of Public 
      Health and Information Sciences, University of Louisville, Louisville, KY, USA.
FAU - Brock, Guy
AU  - Brock G
AD  - Department of Biostatistics and Bioinformatics, School of Public Health and 
      Information Sciences, University of Louisville, Louisville, KY, USA; Birth 
      Defects Center, University of Louisville, Louisville, KY, USA.
FAU - Greene, Robert M
AU  - Greene RM
AD  - Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of 
      Louisville, Louisville, KY, USA; Birth Defects Center, University of Louisville, 
      Louisville, KY, USA.
FAU - Pisano, M Michele
AU  - Pisano MM
AD  - Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of 
      Louisville, Louisville, KY, USA; Birth Defects Center, University of Louisville, 
      Louisville, KY, USA.
LA  - eng
GR  - P20 GM103453/GM/NIGMS NIH HHS/United States
GR  - P20 GM103453-10/GM/NIGMS NIH HHS/United States
GR  - R21 DA027466/DA/NIDA NIH HHS/United States
GR  - NIH R21DA027466/DA/NIDA NIH HHS/United States
GR  - P20 RR017702/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20140128
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Smoke)
SB  - IM
MH  - Animals
MH  - Birth Weight
MH  - Female
MH  - Fetal Growth Retardation/*etiology/metabolism/pathology
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Glycolysis/drug effects
MH  - Hippocampus/*drug effects/metabolism/pathology
MH  - Lipid Metabolism/drug effects
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Metabolomics/methods
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nerve Tissue Proteins/biosynthesis/genetics/*metabolism
MH  - Neurogenesis/drug effects
MH  - Neurons/*drug effects/metabolism/pathology
MH  - Oxidative Phosphorylation/drug effects
MH  - Proteomics/methods
MH  - Random Allocation
MH  - Smoke/*adverse effects
MH  - Nicotiana/*chemistry
PMC - PMC4067966
MID - NIHMS569471
OTO - NOTNLM
OT  - Cigarette smoke
OT  - Development
OT  - Hippocampus
OT  - Metabolome
OT  - Proteome
OT  - Tobacco
EDAT- 2014/02/04 06:00
MHDA- 2014/05/28 06:00
PMCR- 2015/03/20
CRDT- 2014/02/04 06:00
PHST- 2013/08/26 00:00 [received]
PHST- 2013/12/03 00:00 [revised]
PHST- 2014/01/17 00:00 [accepted]
PHST- 2014/02/04 06:00 [entrez]
PHST- 2014/02/04 06:00 [pubmed]
PHST- 2014/05/28 06:00 [medline]
PHST- 2015/03/20 00:00 [pmc-release]
AID - S0300-483X(14)00007-9 [pii]
AID - 10.1016/j.tox.2014.01.006 [doi]
PST - ppublish
SO  - Toxicology. 2014 Mar 20;317:40-9. doi: 10.1016/j.tox.2014.01.006. Epub 2014 Jan 
      28.