PMID- 24486851
OWN - NLM
STAT- MEDLINE
DCOM- 20140519
LR  - 20211021
IS  - 1090-2430 (Electronic)
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 254
DP  - 2014 Apr
TI  - Prenatal cigarette smoke exposure causes hyperactivity and aggressive behavior: 
      role of altered catecholamines and BDNF.
PG  - 145-52
LID - S0014-4886(14)00029-6 [pii]
LID - 10.1016/j.expneurol.2014.01.016 [doi]
AB  - Smoking during pregnancy is associated with a variety of untoward effects on the 
      offspring. However, recent epidemiological studies have brought into question 
      whether the association between neurobehavioral deficits and maternal smoking is 
      causal. We utilized an animal model of maternal smoking to determine the effects 
      of prenatal cigarette smoke (CS) exposure on neurobehavioral development. 
      Pregnant mice were exposed to either filtered air or mainstream CS from gestation 
      day (GD) 4 to parturition for 4h/d and 5d/wk, with each exposure producing 
      maternal plasma concentration of cotinine equivalent to smoking <1 pack of 
      cigarettes per day (25ng/ml plasma cotinine level). Pups were weaned at postnatal 
      day (PND) 21 and behavior was assessed at 4weeks of age and again at 4-6months of 
      age. Male, but not female, offspring of CS-exposed dams demonstrated a 
      significant increase in locomotor activity during adolescence and adulthood that 
      was ameliorated by methylphenidate treatment. Additionally, male offspring 
      exhibited increased aggression, as evidenced by decreased latency to attack and 
      number of attacks in a resident-intruder task. These behavioral abnormalities 
      were accompanied by a significant decrease in striatal and cortical dopamine and 
      serotonin and a significant reduction in brain-derived neurotrophic factor (BDNF) 
      mRNA and protein. Taken in concert, these data demonstrate that prenatal exposure 
      to CS produces behavioral alterations in mice that are similar to those observed 
      in epidemiological studies linking maternal smoking to neurodevelopmental 
      disorders. Further, these data also suggest a role for monaminergic and BDNF 
      alterations in these effects.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Yochum, Carrie
AU  - Yochum C
AD  - Environmental and Occupational Health Sciences Institute, Rutgers, The State 
      University of New Jersey, Piscataway, NJ 08854, USA; Department of Environmental 
      and Occupational Medicine, Rutgers Robert Wood Johnson Medical School, 
      Piscataway, NJ 08854, USA.
FAU - Doherty-Lyon, Shannon
AU  - Doherty-Lyon S
AD  - Department of Environmental Medicine, New York University School of Medicine, 
      Tuxedo, NY 10987, USA.
FAU - Hoffman, Carol
AU  - Hoffman C
AD  - Department of Environmental Medicine, New York University School of Medicine, 
      Tuxedo, NY 10987, USA.
FAU - Hossain, Muhammad M
AU  - Hossain MM
AD  - Environmental and Occupational Health Sciences Institute, Rutgers, The State 
      University of New Jersey, Piscataway, NJ 08854, USA; Department of Environmental 
      and Occupational Medicine, Rutgers Robert Wood Johnson Medical School, 
      Piscataway, NJ 08854, USA.
FAU - Zelikoff, Judith T
AU  - Zelikoff JT
AD  - Department of Environmental Medicine, New York University School of Medicine, 
      Tuxedo, NY 10987, USA. Electronic address: Judith.zelikoff@nyumc.org.
FAU - Richardson, Jason R
AU  - Richardson JR
AD  - Environmental and Occupational Health Sciences Institute, Rutgers, The State 
      University of New Jersey, Piscataway, NJ 08854, USA; Department of Environmental 
      and Occupational Medicine, Rutgers Robert Wood Johnson Medical School, 
      Piscataway, NJ 08854, USA. Electronic address: Jricha3@eohsi.rutgers.edu.
LA  - eng
GR  - P30ES000260/ES/NIEHS NIH HHS/United States
GR  - T32 ES007148/ES/NIEHS NIH HHS/United States
GR  - P30 ES005022/ES/NIEHS NIH HHS/United States
GR  - P30 ES000260/ES/NIEHS NIH HHS/United States
GR  - R01ES015991/ES/NIEHS NIH HHS/United States
GR  - T32ES007148/ES/NIEHS NIH HHS/United States
GR  - R01 ES015991/ES/NIEHS NIH HHS/United States
GR  - P30ES005022/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140130
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Catecholamines)
RN  - 0 (Tobacco Smoke Pollution)
SB  - IM
MH  - Aggression/*physiology
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Catecholamines/*metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Hyperkinesis/*etiology/metabolism
MH  - Litter Size
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Motor Activity/physiology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*etiology/metabolism
MH  - Sex Characteristics
MH  - Tobacco Smoke Pollution/*adverse effects
PMC - PMC3982151
MID - NIHMS562590
OTO - NOTNLM
OT  - ADHD
OT  - Aggression
OT  - BDNF
OT  - Dopamine
OT  - Hyperactivity
OT  - Maternal smoking
OT  - Nicotine
EDAT- 2014/02/04 06:00
MHDA- 2014/05/20 06:00
PMCR- 2015/04/01
CRDT- 2014/02/04 06:00
PHST- 2013/10/07 00:00 [received]
PHST- 2014/01/16 00:00 [revised]
PHST- 2014/01/18 00:00 [accepted]
PHST- 2014/02/04 06:00 [entrez]
PHST- 2014/02/04 06:00 [pubmed]
PHST- 2014/05/20 06:00 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - S0014-4886(14)00029-6 [pii]
AID - 10.1016/j.expneurol.2014.01.016 [doi]
PST - ppublish
SO  - Exp Neurol. 2014 Apr;254:145-52. doi: 10.1016/j.expneurol.2014.01.016. Epub 2014 
      Jan 30.