PMID- 24486968
OWN - NLM
STAT- MEDLINE
DCOM- 20140409
LR  - 20181202
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 65
DP  - 2014 Apr
TI  - Transport of persistent organic pollutants across the human placenta.
PG  - 107-15
LID - S0160-4120(14)00009-9 [pii]
LID - 10.1016/j.envint.2014.01.004 [doi]
AB  - Prenatal life is the most sensitive stage of human development to environmental 
      pollutants. Early exposure to persistent organic pollutants (POPs) may increase 
      the risk of adverse health effects during childhood. The mechanisms of 
      transference of POPs during pregnancy are still not well understood. The present 
      study is aimed to investigate the transfer of POPs between mother and fetus. The 
      concentrations of 14 organochlorine pesticides, 7 polychlorinated biphenyls 
      (PCBs) and 14 polybromodiphenyl ether (PBDEs) congeners have been measured in 308 
      maternal serum samples, their respective umbilical cords and 50 placental tissues 
      from a mother-infant cohort representative of Spanish general population. In 
      general, the adjusted lipid-basis concentrations were higher in maternal serum 
      than in cord serum and placenta. The concentrations of most pollutants between 
      maternal serum and cord serum and between maternal serum and placenta were 
      significantly correlated. These distributions were consistent with a predominant 
      maternal source that transfers the pollutants into the placenta and the fetus. 
      However, this distribution did not correspond to passive diffusion of these 
      compounds between these tissues according to lipid content. The compounds more 
      readily metabolized were higher in newborns, which suggest that differences in 
      metabolic capabilities may be responsible of the observed variations in POP 
      distributions between mother and newborns. Prenatal exposure to 4,4'-DDT and some 
      PBDEs such as BDE 99 and BDE 209 is much higher than it could be anticipated from 
      the composition of maternal serum. POP exposure assessment studies of newborns 
      may overlook the effects of some of these pollutants if they only consider 
      maternal determinations.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Vizcaino, Esther
AU  - Vizcaino E
AD  - Unit of Molecular Cancer Epidemiology, Universitary Institute of Oncology of the 
      Principality of Asturias (IUOPA), Spain; Department of Preventive Medicine and 
      Public Health, University of Oviedo, Julian Claveria, s/n, 33006 Oviedo, 
      Asturias, Spain; Department of Environmental Chemistry, Institute of 
      Environmental Assessment and Water Research (IDAEA-CSIC), Jordi Girona, 18, 08034 
      Barcelona, Catalonia, Spain. Electronic address: esther.vizcaino@idaea.csic.es.
FAU - Grimalt, Joan O
AU  - Grimalt JO
AD  - Department of Environmental Chemistry, Institute of Environmental Assessment and 
      Water Research (IDAEA-CSIC), Jordi Girona, 18, 08034 Barcelona, Catalonia, Spain.
FAU - Fernandez-Somoano, Ana
AU  - Fernandez-Somoano A
AD  - Unit of Molecular Cancer Epidemiology, Universitary Institute of Oncology of the 
      Principality of Asturias (IUOPA), Spain; Spanish Consortium for Research on 
      Epidemiology and Public Health (CIBERESP), Melchor Fernandez Almagro, 3-5, 28029, 
      Madrid, Spain.
FAU - Tardon, Adonina
AU  - Tardon A
AD  - Unit of Molecular Cancer Epidemiology, Universitary Institute of Oncology of the 
      Principality of Asturias (IUOPA), Spain; Spanish Consortium for Research on 
      Epidemiology and Public Health (CIBERESP), Melchor Fernandez Almagro, 3-5, 28029, 
      Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140128
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (2,2',4,4',5-brominated diphenyl ether)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Lipids)
RN  - 0 (Pesticides)
RN  - CIW5S16655 (DDT)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - N80BQ29A0H (decabromobiphenyl ether)
SB  - IM
MH  - Adult
MH  - DDT/analysis/blood/metabolism
MH  - Environmental Monitoring
MH  - Environmental Pollutants/analysis/*blood/*metabolism
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Fetus/chemistry/metabolism
MH  - Halogenated Diphenyl Ethers/analysis/blood/metabolism
MH  - Humans
MH  - Hydrocarbons, Chlorinated/analysis/blood/metabolism
MH  - Infant
MH  - Infant, Newborn
MH  - Lipids/analysis
MH  - *Maternal Exposure
MH  - Pesticides/analysis/blood/metabolism
MH  - Placenta/*chemistry/*metabolism
MH  - Polychlorinated Biphenyls/analysis/blood/metabolism
MH  - Pregnancy
MH  - Spain
OTO - NOTNLM
OT  - Maternal serum
OT  - Persistent organic pollutants
OT  - Placenta
OT  - Prenatal exposure
OT  - Transplacental transfer
OT  - Umbilical cord serum
EDAT- 2014/02/04 06:00
MHDA- 2014/04/10 06:00
CRDT- 2014/02/04 06:00
PHST- 2013/09/27 00:00 [received]
PHST- 2013/12/19 00:00 [revised]
PHST- 2014/01/02 00:00 [accepted]
PHST- 2014/02/04 06:00 [entrez]
PHST- 2014/02/04 06:00 [pubmed]
PHST- 2014/04/10 06:00 [medline]
AID - S0160-4120(14)00009-9 [pii]
AID - 10.1016/j.envint.2014.01.004 [doi]
PST - ppublish
SO  - Environ Int. 2014 Apr;65:107-15. doi: 10.1016/j.envint.2014.01.004. Epub 2014 Jan 
      28.