PMID- 2448703
OWN - NLM
STAT- MEDLINE
DCOM- 19880309
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 26
IP  - 11
DP  - 1987 Nov
TI  - Differences in the central serotonergic effects of methylenedioxymethamphetamine 
      (MDMA) in mice and rats.
PG  - 1657-61
AB  - The effects of subcutaneous injection of 3,4-methylenedioxymethamphetamine 
      (MDMA), a psychoactive amphetamine congener, on mouse central monoaminergic 
      systems were assessed and compared to effects in rats. Whereas neostriatal 
      concentrations of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in mouse 
      were transiently decreased after a single moderately high dose of MDMA (15 
      mg/kg), mouse neostriatal or hippocampal tryptophan hydroxylase activity was not 
      significantly affected, even after a dose of 60 mg/kg. These results are in 
      contrast to effects in rats, in which a single 10 mg/kg dose of MDMA induced 
      immediate and prolonged decreases in both central tryptophan hydroxylase activity 
      and 5-hydroxyindole concentrations. Decreases in mouse central tryptophan 
      hydroxylase activity, and prolonged decreases in mouse 5-hydroxyindole 
      concentrations, were observed only after multiple doses of MDMA, suggesting that 
      the duration of exposure may be an important determinant of toxic effects. These 
      results show mice to be less susceptible than rats to MDMA-induced neurotoxicity, 
      and are discussed in terms of possible interspecies differences in MDMA 
      pharmacokinetics.
FAU - Stone, D M
AU  - Stone DM
AD  - Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 
      84112.
FAU - Hanson, G R
AU  - Hanson GR
FAU - Gibb, J W
AU  - Gibb JW
LA  - eng
GR  - DA 04222/DA/NIDA NIH HHS/United States
GR  - DA 08869/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Amphetamines)
RN  - 0 (Biogenic Amines)
RN  - 0 (Receptors, Serotonin)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - EC 1.14.16.4 (Tryptophan Hydroxylase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*toxicity
MH  - Amphetamines/*toxicity
MH  - Animals
MH  - Biogenic Amines/metabolism
MH  - Brain/enzymology
MH  - Corpus Striatum/drug effects/metabolism
MH  - Hippocampus/drug effects/metabolism
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Serotonin/*drug effects
MH  - Serotonin/metabolism
MH  - Species Specificity
MH  - Time Factors
MH  - Tryptophan Hydroxylase/metabolism
EDAT- 1987/11/01 00:00
MHDA- 1987/11/01 00:01
CRDT- 1987/11/01 00:00
PHST- 1987/11/01 00:00 [pubmed]
PHST- 1987/11/01 00:01 [medline]
PHST- 1987/11/01 00:00 [entrez]
AID - 10.1016/0028-3908(87)90017-7 [doi]
PST - ppublish
SO  - Neuropharmacology. 1987 Nov;26(11):1657-61. doi: 10.1016/0028-3908(87)90017-7.