PMID- 24487616 OWN - NLM STAT- MEDLINE DCOM- 20150519 LR - 20211021 IS - 1433-8491 (Electronic) IS - 0940-1334 (Linking) VI - 264 IP - 7 DP - 2014 Oct TI - The effects of exercise on oxidative stress (TBARS) and BDNF in severely depressed inpatients. PG - 605-13 LID - 10.1007/s00406-014-0489-5 [doi] AB - Exercise can be an effective treatment for depression. Although the efficacy of exercise is well established, little is known concerning the biological changes associated with the antidepressant effects of exercise. A randomized, controlled trial was conducted to evaluate the effects of adding exercise to the usual treatment on the thiobarbituric acid-reactive substances (TBARS) and brain-derived neurotrophic factor (BDNF) serum levels of severely depressed inpatients. Twenty-six participants were randomized to an exercise group (n=15, exercise+treatment as usual) or a control group (n=11, treatment as usual). The participants in the exercise group completed a targeted dose of 16.5 kcal/kg/week of aerobic exercise, three times per week, throughout their hospitalizations. The control group did not exercise during their hospitalizations. The mean hospitalization length was of 21.63 (4.5)x23.82 (5.7) days for exercise and control groups, respectively. The exercise group performed a median of nine sessions. After adjusting for previous tobacco use, a significant groupxtime interaction was found for TBARS serum levels (p=0.02). A post hoc Bonferroni test revealed differences between the exercise and control groups at discharge. A significant time effect (p<0.001) but no groupxtime interaction was found (p=0.13) for BDNF serum levels. Adding exercise to the usual treatment of severely depressed inpatients decreases the TBARS serum levels of severely depressed inpatients after 3 weeks. Adding exercise had no additional effects on BDNF serum levels. FAU - Schuch, Felipe Barreto AU - Schuch FB AD - Programa de Pos-Graduacao em Ciencias Medicas: Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, felipe.schuch@ufrgs.br. FAU - Vasconcelos-Moreno, Mirela Paiva AU - Vasconcelos-Moreno MP FAU - Borowsky, Carolina AU - Borowsky C FAU - Zimmermann, Ana Beatriz AU - Zimmermann AB FAU - Wollenhaupt-Aguiar, Bianca AU - Wollenhaupt-Aguiar B FAU - Ferrari, Pamela AU - Ferrari P FAU - de Almeida Fleck, Marcelo Pio AU - de Almeida Fleck MP LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20140201 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 RN - 0 (Antidepressive Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Thiobarbituric Acid Reactive Substances) SB - IM MH - Adult MH - Analysis of Variance MH - Antidepressive Agents/therapeutic use MH - Brain-Derived Neurotrophic Factor/*blood MH - Depression/drug therapy/metabolism/physiopathology/*rehabilitation MH - Enzyme-Linked Immunosorbent Assay MH - Exercise/*physiology MH - Exercise Therapy/*methods MH - Female MH - Heart Rate MH - Humans MH - Male MH - Middle Aged MH - Oxidative Stress/*physiology MH - Oxygen Consumption MH - Psychiatric Status Rating Scales MH - Retrospective Studies MH - Thiobarbituric Acid Reactive Substances/metabolism EDAT- 2014/02/04 06:00 MHDA- 2015/05/20 06:00 CRDT- 2014/02/04 06:00 PHST- 2013/10/01 00:00 [received] PHST- 2014/01/24 00:00 [accepted] PHST- 2014/02/04 06:00 [entrez] PHST- 2014/02/04 06:00 [pubmed] PHST- 2015/05/20 06:00 [medline] AID - 10.1007/s00406-014-0489-5 [doi] PST - ppublish SO - Eur Arch Psychiatry Clin Neurosci. 2014 Oct;264(7):605-13. doi: 10.1007/s00406-014-0489-5. Epub 2014 Feb 1.