PMID- 24488061
OWN - NLM
STAT- MEDLINE
DCOM- 20141204
LR  - 20211021
IS  - 1437-9813 (Electronic)
IS  - 0179-0358 (Linking)
VI  - 30
IP  - 4
DP  - 2014 Apr
TI  - Proton pump inhibitors for reflux therapy in infants: effectiveness determined by 
      impedance pH monitoring.
PG  - 381-5
LID - 10.1007/s00383-013-3458-6 [doi]
AB  - PURPOSE: To evaluate the influence of proton pump inhibitors (PPI) in 
      predominantly milk-fed infants with symptoms of GERD by 24-h pH-multichannel 
      intraluminal impedance (24-h pH-MII). METHODS: Ten infants (8 males and 2 
      females) with a mean gestational age of 39 weeks (28-40) were included. 24-h 
      pH-MII was performed before prescription and during intake of PPI. Total acid 
      exposure time, bolus exposure time (acidic/non-acidic/total) and the number of 
      refluxes (acidic/non-acidic/total) were determined. Clinical symptoms were 
      recorded and used to calculate the Reflux Symptom Index (RSI) and the Symptom 
      Severity Index (SSI). RESULTS: There was a significant decrease in the number of 
      acidic refluxes, total acid exposure and acidic bolus exposure time. However, 
      this went along with a significant increase in non-acidic bolus exposure time. 
      The total number of refluxes and the total bolus exposure time remained 
      unchanged. Under PPI, a decrease of SSI and RSI for pain-related symptoms could 
      be observed. For respiratory symptoms and vomiting however no significant changes 
      could be demonstrated. CONCLUSIONS: Under PPI, an improvement of pain-related 
      symptoms could be shown. The decrease of acid exposure went along with an 
      increase of non-acidic refluxes resulting in almost constant total reflux 
      numbers. This finding is interpreted as main reason for some persisting symptoms 
      despite adequate PPI dosage. Concluding from our data PPI therapy should only be 
      indicated in case of pain, but has no effect in case of vomiting or recurrent 
      respiratory symptoms.
FAU - Castellani, Christoph
AU  - Castellani C
AD  - Department of Pediatric and Adolescent Surgery, Medical University Graz, 
      Auenbruggerplatz 34, 8036, Graz, Austria, christoph.castellani@medunigraz.at.
FAU - Huber-Zeyringer, Andrea
AU  - Huber-Zeyringer A
FAU - Bachmaier, Gerhard
AU  - Bachmaier G
FAU - Saxena, Amulya K
AU  - Saxena AK
FAU - Hollwarth, Michael E
AU  - Hollwarth ME
LA  - eng
PT  - Journal Article
DEP - 20140201
PL  - Germany
TA  - Pediatr Surg Int
JT  - Pediatric surgery international
JID - 8609169
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Electric Impedance
MH  - *Esophageal pH Monitoring
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy/*physiopathology
MH  - Humans
MH  - Infant
MH  - Male
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2014/02/04 06:00
MHDA- 2014/12/15 06:00
CRDT- 2014/02/04 06:00
PHST- 2013/12/20 00:00 [accepted]
PHST- 2014/02/04 06:00 [entrez]
PHST- 2014/02/04 06:00 [pubmed]
PHST- 2014/12/15 06:00 [medline]
AID - 10.1007/s00383-013-3458-6 [doi]
PST - ppublish
SO  - Pediatr Surg Int. 2014 Apr;30(4):381-5. doi: 10.1007/s00383-013-3458-6. Epub 2014 
      Feb 1.