PMID- 24489687
OWN - NLM
STAT- MEDLINE
DCOM- 20141218
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 1
DP  - 2014
TI  - Comparison of corneal epithelial and stromal thickness distributions between eyes 
      with keratoconus and healthy eyes with corneal astigmatism >/= 2.0 D.
PG  - e85994
LID - 10.1371/journal.pone.0085994 [doi]
LID - e85994
AB  - PURPOSE: To identify corneal epithelial- and stromal-thickness distribution 
      patterns in keratoconus using spectral-domain optical coherence tomography 
      (SD-OCT). PATIENTS AND METHODS: We analyzed SD-OCT findings in 20 confirmed cases 
      of keratoconus (group 1) and in 20 healthy subjects with corneal astigmatism >/= 2 
      D (group 2). Epithelial and stromal thicknesses were measured at 11 strategic 
      locations along the steepest and flattest meridians, previously located by 
      corneal topography. Vertical mirrored symmetry superimposition was used in the 
      statistical analysis. RESULTS: The mean maximum keratometry measurements in 
      groups 1 and 2 were 47.9 +/- 2.9 D (range, 41.8-52.8) and 45.6 +/- 1.1 D (range, 
      42.3-47.5), respectively, with mean corneal cylinders of 3.3 +/- 2.2 D (range, 
      0.5-9.5) and 3.6 +/- 1.2 D (range, 2.0-6.4), respectively. The mean epithelial 
      thickness along the steepest meridian in group 1 was the lowest (37.4 +/- 4.4 microm) 
      at 1.2 mm inferotemporally and the highest (59.3 +/- 4.4 microm) at 1.4 mm supranasally 
      from the corneal vertex. There was only a small deviation in thickness along the 
      steepest meridian in group 2, as well as along the flattest meridians in both 
      groups. The stromal thickness distribution in the two groups was similar to the 
      epithelial, while the stromal thickness was generally lower in group 1 than in 
      group 2. CONCLUSIONS: SD-OCT provides details about the distribution of corneal 
      epithelial and stromal thicknesses. The epithelium and stroma in keratoconic eyes 
      were thinner inferotemporally and thicker supranasally compared with control 
      eyes. The distribution pattern was more distinct in epithelium than in stroma. 
      This finding may help improve the early diagnosis of keratoconus. TRIAL 
      REGISTRATION: ClinicalTrials.gov NCT02023619.
FAU - Zhou, Wen
AU  - Zhou W
AD  - SynsLaser Kirurgi AS, Tromso, Troms, Norway.
FAU - Stojanovic, Aleksandar
AU  - Stojanovic A
AD  - SynsLaser Kirurgi AS, Tromso, Troms, Norway ; Eye Department, University Hospital 
      North Norway, Tromso, Troms, Norway.
LA  - eng
SI  - ClinicalTrials.gov/NCT02023619
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140128
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Astigmatism/*pathology
MH  - Cornea/*pathology
MH  - Female
MH  - Humans
MH  - Keratoconus/*pathology
MH  - Male
MH  - Middle Aged
MH  - Tomography, Optical Coherence/*methods
MH  - Young Adult
PMC - PMC3904857
COIS- Competing Interests: WZ and AS are employed by SynsLaser Kirurgi AS. This does 
      not alter the authors' adherence to all the PLOS ONE policies on sharing data and 
      materials.
EDAT- 2014/02/04 06:00
MHDA- 2014/12/19 06:00
PMCR- 2014/01/28
CRDT- 2014/02/04 06:00
PHST- 2013/10/11 00:00 [received]
PHST- 2013/11/25 00:00 [accepted]
PHST- 2014/02/04 06:00 [entrez]
PHST- 2014/02/04 06:00 [pubmed]
PHST- 2014/12/19 06:00 [medline]
PHST- 2014/01/28 00:00 [pmc-release]
AID - PONE-D-13-41546 [pii]
AID - 10.1371/journal.pone.0085994 [doi]
PST - epublish
SO  - PLoS One. 2014 Jan 28;9(1):e85994. doi: 10.1371/journal.pone.0085994. eCollection 
      2014.