PMID- 24491024
OWN - NLM
STAT- MEDLINE
DCOM- 20150720
LR  - 20190116
IS  - 1029-2403 (Electronic)
IS  - 1026-8022 (Linking)
VI  - 55
IP  - 11
DP  - 2014 Nov
TI  - Long-term effect of curcumin down-regulates expression of tumor necrosis factor-alpha 
      and interleukin-6 via modulation of E26 transformation-specific protein and 
      nuclear factor-kappaB transcription factors in livers of lymphoma bearing mice.
PG  - 2627-36
LID - 10.3109/10428194.2014.889824 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) are typical 
      multifunctional proinflammatory cytokines involved actively in the regulation of 
      immunity, hematopoiesis, inflammation and carcinogenesis. Coordinated regulation 
      of these cytokines could be required for effective regulation of early phase 
      inflammation and cancer progression. The present work was aimed to analyze the 
      anti-carcinogenic action of curcumin on the expression of TNF-alpha and IL-6 even 
      after withdrawal of treatment. Up-regulated expressions of TNF-alpha and IL-6 in 
      terms of mRNA and protein levels in lymphoma bearing mice were significantly 
      down-regulated by curcumin as compared to normal. Electrophoretic mobility shift 
      assay (EMSA) results revealed that curcumin reduced binding of nuclear protein 
      with ETS and NF-kappaB binding elements of TNF-alpha and IL-6 promoters, respectively. 
      The anti-carcinogenic effect of curcumin against lymphoma progression has been 
      reported previously. In continuation, the present study suggests that the 
      long-term effect of curcumin may contribute to attenuate cancer progression via 
      the down-regulation of TNF-alpha and IL-6 modulated by E26 transformation-specific 
      protein (ETS) and nuclear factor-kappaB (NF-kappaB), respectively.
FAU - Das, Laxmidhar
AU  - Das L
AD  - Biochemistry and Molecular Biology Laboratory, Department of Zoology (Center for 
      Advanced Study), Banaras Hindu University , Varanasi , India.
FAU - Vinayak, Manjula
AU  - Vinayak M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140310
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Ets1 protein, mouse)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Proto-Oncogene Protein c-ets-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Blotting, Western
MH  - Curcumin/*pharmacology
MH  - Disease Progression
MH  - Down-Regulation/drug effects
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Interleukin-6/genetics/*metabolism
MH  - Lymphoma/*drug therapy/genetics/metabolism
MH  - Mice, Inbred AKR
MH  - NF-kappa B/*metabolism
MH  - Promoter Regions, Genetic/genetics
MH  - Protein Binding
MH  - Proto-Oncogene Protein c-ets-1/*metabolism
MH  - Response Elements/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/genetics/*metabolism
OTO - NOTNLM
OT  - Lymphoma
OT  - carcinogenesis
OT  - curcumin
OT  - cytokines
OT  - microenvironment
EDAT- 2014/02/05 06:00
MHDA- 2015/07/21 06:00
CRDT- 2014/02/05 06:00
PHST- 2014/02/05 06:00 [entrez]
PHST- 2014/02/05 06:00 [pubmed]
PHST- 2015/07/21 06:00 [medline]
AID - 10.3109/10428194.2014.889824 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2014 Nov;55(11):2627-36. doi: 10.3109/10428194.2014.889824. Epub 
      2014 Mar 10.