PMID- 24491062
OWN - NLM
STAT- MEDLINE
DCOM- 20140711
LR  - 20211203
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 30
IP  - 2
DP  - 2014 Feb
TI  - [Correlation of HLA-DRB1 gene polymorphism and aplastic anemia in Xinjiang Han 
      people].
PG  - 188-90
AB  - OBJECTIVE: To investigate the correlation between the human leukocyte antigen 
      (HLA) DRB1 and the aplastic anemia (AA). METHODS: A total of 243 Han ethnic 
      people in Xinjiang were enrolled for this study. Among them, 43 people were 
      diagnosed as AA and the other 200 were healthy controls. All the blood samples of 
      the 243 people were tested by polymerase chain reaction-sequence specific primer 
      (PCR-SSP) DNA typing techniques. Then their allele frequencies were compared by 
      the statistical analysis of x(2); test to study the correlation between the 
      HLA-DRB1 gene polymorphism and the AA in Xinjiang. RESULTS: The HLA-DRB1 allele 
      frequency distributions in AA patients and healthy controls were similar, that 
      was, DRB1*15 allele frequency was highest, while DRB1*4, DRB1*7, DRB1*9, DRB1*12 
      expressions were higher, and the lowest frequency was DRB1*17. The frequency of 
      HLA-DRB1*8 allele in the AA group (13.73%) was significantly higher than that in 
      healthy controls (6.99%) (OR=2.202, P<0.05). The frequency of HLA-DRB1*12, 
      DRB1*14 alleles were lower in AA group than in healthy control group, but the 
      difference was not statistically significant (P>0.05). However, compared with the 
      healthy control group, the female AA patients had a lower frequency of 
      HLA-DRB1*12 allele (5.41% vs 10.00%, OR=0.2079, P<0.05) and the male AA cases had 
      a lower HLA-DRB1*14 allele (2.11% vs 7.53%, OR=0.1403, P<0.05); The frequency of 
      HLA-DRB1*15 allele in female AA patients was significantly higher than that in 
      healthy control group (27.45% vs 14.56%, OR=2.433, P<0.05). CONCLUSION: The 
      HLA-DRB1*8 could be a susceptibility allele for AA. The HLA-DRB1*12 and the 
      HLA-DRB1*14 could be the antagonistic alleles for female and male AA patients, 
      respectively. The HLA-DRB1*15 could be a susceptibility allele for the female AA 
      patients.
FAU - Wang, Fan
AU  - Wang F
AD  - Blood Center, First Affiliated Hospital, Xinjiang Medical University, Urumqi 
      830054, China.
FAU - Hu, Anhua
AU  - Hu A
AD  - Department of Blood Transfusion, First Affiliated Hospital, Xinjiang Medical 
      University, Urumqi 830054, China.
FAU - Yang, Yan
AU  - Yang Y
AD  - Department of Blood Transfusion, First Affiliated Hospital, Xinjiang Medical 
      University, Urumqi 830054, China.
FAU - Xie, Ping
AU  - Xie P
AD  - Blood Center, First Affiliated Hospital, Xinjiang Medical University, Urumqi 
      830054, China.
FAU - Wang, Xiaona
AU  - Wang X
AD  - Blood Center, First Affiliated Hospital, Xinjiang Medical University, Urumqi 
      830054, China.
FAU - Qu, Jianhua
AU  - Qu J
AD  - Blood Center, First Affiliated Hospital, Xinjiang Medical University, Urumqi 
      830054, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anemia, Aplastic/*genetics
MH  - Case-Control Studies
MH  - China/ethnology
MH  - Ethnicity/*genetics
MH  - Female
MH  - Gene Frequency
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Young Adult
EDAT- 2014/02/05 06:00
MHDA- 2014/07/12 06:00
CRDT- 2014/02/05 06:00
PHST- 2014/02/05 06:00 [entrez]
PHST- 2014/02/05 06:00 [pubmed]
PHST- 2014/07/12 06:00 [medline]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Feb;30(2):188-90.