PMID- 24491075
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20220409
IS  - 1939-2117 (Electronic)
IS  - 0022-006X (Print)
IS  - 0022-006X (Linking)
VI  - 82
IP  - 3
DP  - 2014 Jun
TI  - Mindfulness-oriented recovery enhancement for chronic pain and prescription 
      opioid misuse: results from an early-stage randomized controlled trial.
PG  - 448-459
LID - 10.1037/a0035798 [doi]
AB  - OBJECTIVE: Opioid pharmacotherapy is now the leading treatment for chronic pain, 
      a problem that affects nearly one third of the U.S. population. Given the 
      dramatic rise in prescription opioid misuse and opioid-related mortality, novel 
      behavioral interventions are needed. The purpose of this study was to conduct an 
      early-stage randomized controlled trial of Mindfulness-Oriented Recovery 
      Enhancement (MORE), a multimodal intervention designed to simultaneously target 
      mechanisms underpinning chronic pain and opioid misuse. METHOD: Chronic pain 
      patients (N = 115; mean age = 48 +/- 14 years; 68% female) were randomized to 8 
      weeks of MORE or a support group (SG). Outcomes were measured at pre- and 
      posttreatment, and at 3-month follow-up. The Brief Pain Inventory was used to 
      assess changes in pain severity and interference. Changes in opioid use disorder 
      status were measured by the Current Opioid Misuse Measure. Desire for opioids, 
      stress, nonreactivity, reinterpretation of pain sensations, and reappraisal were 
      also evaluated. RESULTS: MORE participants reported significantly greater 
      reductions in pain severity (p = .038) and interference (p = .003) than SG 
      participants, which were maintained by 3-month follow-up and mediated by 
      increased nonreactivity and reinterpretation of pain sensations. Compared with SG 
      participants, participants in MORE evidenced significantly less stress arousal (p 
      = .034) and desire for opioids (p = .027), and were significantly more likely to 
      no longer meet criteria for opioid use disorder immediately following treatment 
      (p = .05); however, these effects were not sustained at follow-up. CONCLUSIONS: 
      Findings demonstrate preliminary feasibility and efficacy of MORE as a treatment 
      for co-occurring prescription opioid misuse and chronic pain. (PsycINFO Database 
      Record (c) 2014 APA, all rights reserved).
FAU - Garland, Eric L
AU  - Garland EL
AD  - College of Social Work.
FAU - Manusov, Eron G
AU  - Manusov EG
AD  - Duke Southern Regional Area Health Education Center.
FAU - Froeliger, Brett
AU  - Froeliger B
AUID- ORCID: 0000-0001-9451-9900
AD  - Department of Neuroscience.
FAU - Kelly, Amber
AU  - Kelly A
AD  - School of Social Work, Smith College.
FAU - Williams, Jaclyn M
AU  - Williams JM
AD  - College of Social Work, Florida State University.
FAU - Howard, Matthew O
AU  - Howard MO
AD  - School of Social Work, University of North Carolina.
LA  - eng
GR  - R03 DA032517/DA/NIDA NIH HHS/United States
GR  - R34 DA037005/DA/NIDA NIH HHS/United States
GR  - R34DA037005/DA/NIDA NIH HHS/United States
GR  - R03DA032517/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140203
PL  - United States
TA  - J Consult Clin Psychol
JT  - Journal of consulting and clinical psychology
JID - 0136553
RN  - 0 (Analgesics, Opioid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Analgesics, Opioid/*administration & dosage/*adverse effects
MH  - Arousal
MH  - Chronic Pain/drug therapy/psychology/*therapy
MH  - Combined Modality Therapy
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mindfulness
MH  - Opioid-Related Disorders/*etiology/*therapy
MH  - Treatment Outcome
MH  - United States
MH  - Veterans
PMC - PMC4076008
MID - NIHMS582118
EDAT- 2014/02/05 06:00
MHDA- 2015/11/17 06:00
PMCR- 2015/06/01
CRDT- 2014/02/05 06:00
PHST- 2014/02/05 06:00 [entrez]
PHST- 2014/02/05 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - 2014-03888-001 [pii]
AID - 10.1037/a0035798 [doi]
PST - ppublish
SO  - J Consult Clin Psychol. 2014 Jun;82(3):448-459. doi: 10.1037/a0035798. Epub 2014 
      Feb 3.