PMID- 24492743
OWN - NLM
STAT- MEDLINE
DCOM- 20141118
LR  - 20190608
IS  - 1880-2206 (Electronic)
IS  - 1347-3182 (Linking)
VI  - 13
IP  - 1
DP  - 2014
TI  - Serial scans in healthy volunteers following intravenous administration of 
      gadoteridol: time course of contrast enhancement in various cranial fluid spaces.
PG  - 7-13
AB  - PURPOSE: Heavily T2-weighted, 3-dimensional, fluid-attenuated inversion recovery 
      (hT2W-3D-FLAIR) imaging has been reported to detect low concentrations of 
      gadolinium-based contrast media (GBCM) in the anterior eye segment (AES), 
      subarachnoid space (SAS), and labyrinthine perilymph as well as in the 
      cerebrospinal fluid (CSF) of the internal auditory canal (IAC) 4 hours after 
      intravenous administration of a single dose (IV-SD-GBCM) in patients with inner 
      ear disorders. To elucidate the time course of contrast enhancement in healthy 
      volunteers, we obtained hT2W-3D-FLAIR serially after IV-SD-GBCM. MATERIALS AND 
      METHODS: We obtained hT2W-3D-FLAIR before and 0.5, 1.5, 3, 4.5 and 6 hours after 
      IV-SD-GBCM in 6 healthy volunteers and measured signal intensity of the AES, SAS 
      surrounding the optic nerve (SAS-ON), SAS in Meckel's cave (SAS-MC), pontine 
      parenchyma, CSF in the IAC (CSF-IAC), CSF in the ambient cistern (CSF-AC), CSF in 
      the lateral ventricles (CSF-LV), perilymph (PL), and endolymph (EL) in the 
      labyrinth. We then compared averaged values among all time points using analysis 
      of variance (ANOVA). RESULTS: After IV-SD-GBCM, we observed no change in signal 
      intensity in the pontine parenchyma, CSF-LV, or EL and significant enhancement in 
      all other structures. Maximum enhancement was most frequent at 4.5 hours after 
      IV-SD-GBCM in the SAS-ON and PL, at 1.5 hours in the AES and SAS-MC, and at 3 
      hours in the CSF-IAC and CSF-AC. CONCLUSIONS: Contrast enhancement can be 
      detected by hT2W-3D-FLAIR in the AES, SAS-ON, SAS-MC, PL, CSF-IAC, and CSF-AC in 
      healthy volunteers after IV-SD-GBCM. Timing of maximum enhancement differed among 
      locations. These data might serve as basic knowledge for future clinical 
      research.
FAU - Naganawa, Shinji
AU  - Naganawa S
AD  - Department of Radiology, Nagoya University Graduate School of Medicine.
FAU - Suzuki, Kojiro
AU  - Suzuki K
FAU - Yamazaki, Masahiro
AU  - Yamazaki M
FAU - Sakurai, Yasuo
AU  - Sakurai Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140131
PL  - Japan
TA  - Magn Reson Med Sci
JT  - Magnetic resonance in medical sciences : MRMS : an official journal of Japan 
      Society of Magnetic Resonance in Medicine
JID - 101153368
RN  - 0 (Contrast Media)
RN  - 0 (Heterocyclic Compounds)
RN  - 0 (Organometallic Compounds)
RN  - 0199MV609F (gadoteridol)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Anterior Eye Segment/metabolism
MH  - Contrast Media/*pharmacokinetics
MH  - Ear Canal/metabolism
MH  - Gadolinium/cerebrospinal fluid/pharmacokinetics
MH  - Healthy Volunteers
MH  - Heterocyclic Compounds/cerebrospinal fluid/*pharmacokinetics
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Organometallic Compounds/cerebrospinal fluid/*pharmacokinetics
MH  - Perilymph/metabolism
MH  - Subarachnoid Space/metabolism
MH  - Time Factors
EDAT- 2014/02/05 06:00
MHDA- 2014/11/19 06:00
CRDT- 2014/02/05 06:00
PHST- 2014/02/05 06:00 [entrez]
PHST- 2014/02/05 06:00 [pubmed]
PHST- 2014/11/19 06:00 [medline]
AID - DN/JST.JSTAGE/mrms/2013-0056 [pii]
AID - 10.2463/mrms.2013-0056 [doi]
PST - ppublish
SO  - Magn Reson Med Sci. 2014;13(1):7-13. doi: 10.2463/mrms.2013-0056. Epub 2014 Jan 
      31.