PMID- 24492933
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20211021
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 252
IP  - 8
DP  - 2014 Aug
TI  - Early postoperative changes of the foveal surface in epiretinal membranes: 
      comparison of 23-gauge macular surgery with air vs. balanced salt solution.
PG  - 1213-9
LID - 10.1007/s00417-014-2573-y [doi]
AB  - OBJECTIVE: To analyze the foveal surface using binary image analysis after 
      spectral-domain optical coherence tomography (SD-OCT) following 23-gauge macular 
      surgery in epiretinal membranes (ERM) using either air tamponade (AIR) or 
      balanced salt solution (BSS). METHODS: One hundred twenty-four eyes (124 
      patients) with ERM that had undergone membrane peeling with installation of air 
      or BSS were analyzed retrospectively. Ophthalmic examination was performed at 
      baseline and 3 months. OUTCOME MEASURES: The foveal area and surface symmetry, 
      area matched thickness, area matched contour, and best-corrected visual acuity 
      (BCVA). The OCT images were analyzed after binary conversion with ImageJ 
      software. RESULTS: Eighty eyes (80 patients) of 124 screened patients were 
      included (AIR group: 39 patients, BSS group: 41 patients). Median follow-up time 
      was 14 weeks (range, 9-19 weeks). Three months after surgery, the median 
      horizontal area decreased significantly in both groups (p < 0.0001). At 
      follow-up, the foveal surface symmetry values for the BSS group (median, 
      22.73 mum, range, 0-153) were significantly lower than for the AIR group (median, 
      23.95 mum, range, 0-160.43) (p < 0.0001). The area-matched thickness increased 
      significantly in both groups (p < 0.001). The AIR group showed a significant 
      increase of the area matched contour for the nasal located measurement-areas N1 
      (p < 0.0003), N2 (p < 0.0079), N3 (p < 0.007). The BSS group showed a significant 
      increase of the area-matched contour for the measurement areas N1 (p < 0.019), N2 
      (p < 0.0014), and N4 (p < 0.022). After surgery, median BCVA for both groups 
      increased significantly to 0.3 logMAR. CONCLUSIONS: The analysis of early contour 
      changes after ERM surgery was technically possible. Long-term data have to be 
      looked at before the clinical impact of this methodology can be estimated. 
      Although there were no big differences between both groups (AIR vs. BSS), this 
      could change within a longer and more representative follow-up.
FAU - Leitritz, Martin A
AU  - Leitritz MA
AD  - University Eye-Hospital, Centre for Ophthalmology, Eberhard-Karls University, 
      Schleichstr. 12, 72076, Tuebingen, Germany, martin.leitritz@med.uni-tuebingen.de.
FAU - Ziemssen, Focke
AU  - Ziemssen F
FAU - Voykov, Bogomil
AU  - Voykov B
FAU - Dimopoulos, Spyridon
AU  - Dimopoulos S
FAU - Zobor, Ditta
AU  - Zobor D
FAU - Bartz-Schmidt, Karl U
AU  - Bartz-Schmidt KU
FAU - Gelisken, Faik
AU  - Gelisken F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20140204
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
RN  - 0 (Acetates)
RN  - 0 (BSS solution)
RN  - 0 (Drug Combinations)
RN  - 0 (Minerals)
RN  - 451W47IQ8X (Sodium Chloride)
SB  - IM
MH  - Acetates/*administration & dosage
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Air
MH  - Drug Combinations
MH  - Endotamponade
MH  - Epiretinal Membrane/*surgery
MH  - Female
MH  - Fovea Centralis/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Minerals/*administration & dosage
MH  - *Ophthalmologic Surgical Procedures
MH  - *Postoperative Complications
MH  - Retrospective Studies
MH  - Sodium Chloride/*administration & dosage
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2014/02/05 06:00
MHDA- 2015/01/13 06:00
CRDT- 2014/02/05 06:00
PHST- 2013/10/15 00:00 [received]
PHST- 2014/01/10 00:00 [accepted]
PHST- 2014/01/04 00:00 [revised]
PHST- 2014/02/05 06:00 [entrez]
PHST- 2014/02/05 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
AID - 10.1007/s00417-014-2573-y [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2014 Aug;252(8):1213-9. doi: 
      10.1007/s00417-014-2573-y. Epub 2014 Feb 4.